Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2013, 14(4), 7829-7852; doi:10.3390/ijms14047829
Review

Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways

,
 and *
Received: 19 February 2013; in revised form: 2 April 2013 / Accepted: 3 April 2013 / Published: 10 April 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
View Full-Text   |   Download PDF [587 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate endocytosis and cell signaling. ITSN genes are highly conserved and present in all metazoan genomes examined thus far. Lower eukaryotes have only one ITSN gene, whereas higher eukaryotes have two ITSN genes. ITSN was first identified as an endocytic scaffold protein, and numerous studies reveal a conserved role for ITSN in endocytosis. Subsequently, ITSNs were found to regulate multiple signaling pathways including receptor tyrosine kinases (RTKs), GTPases, and phosphatidylinositol 3-kinase Class 2beta (PI3KC2β). ITSN has also been implicated in diseases such as Down Syndrome (DS), Alzheimer Disease (AD), and other neurodegenerative disorders. This review summarizes the evolutionary conservation of ITSN, the latest research on the role of ITSN in endocytosis, the emerging roles of ITSN in regulating cell signaling pathways, and the involvement of ITSN in human diseases such as DS, AD, and cancer.
Keywords: Intersectin; endocytosis; cell signaling; Ras; PI3KC2β; Down Syndrome; Alzheimer Disease; cancer; neuroblastoma; glioblastoma Intersectin; endocytosis; cell signaling; Ras; PI3KC2β; Down Syndrome; Alzheimer Disease; cancer; neuroblastoma; glioblastoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Hunter, M.P.; Russo, A.; O'Bryan, J.P. Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways. Int. J. Mol. Sci. 2013, 14, 7829-7852.

AMA Style

Hunter MP, Russo A, O'Bryan JP. Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways. International Journal of Molecular Sciences. 2013; 14(4):7829-7852.

Chicago/Turabian Style

Hunter, Michael P.; Russo, Angela; O'Bryan, John P. 2013. "Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways." Int. J. Mol. Sci. 14, no. 4: 7829-7852.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert