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Int. J. Mol. Sci. 2013, 14(4), 7140-7154; doi:10.3390/ijms14047140
Article

Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats

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Received: 11 December 2012; in revised form: 21 March 2013 / Accepted: 25 March 2013 / Published: 28 March 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: This study examined whether Opuntia humifusa (O. humifusa), which is a member of the Cactaceae family, supplementation and acute swimming exercise affect insulin sensitivity and associations with PPAR-γ and PGC-1α protein expression in rats. Thirty-two rats were randomly divided into four groups (HS: high fat diet sedentary group, n = 8; HE: high fat diet acute exercise group, n = 8; OS: 5% O. humifusa supplemented high fat diet sedentary group, n = 8; OE: 5% O. humifusa supplemented high fat diet acute exercise group, n = 8). Rats in the HE and OE swam for 120 min. before being sacrificed. Our results indicated that serum glucose level, fasting insulin level and homeostasis model assessment of insulin resistance (HOMA-IR) in OS were significantly lower compared to those of the HS (p < 0.01, p < 0.05, p < 0.05). In addition, PPAR-γ protein expression in the OS and OE was significantly higher than that of the HS and HE, respectively (p < 0.05, p < 0.01). PGC-1α and GLUT-4 protein expressions in the OS were significantly higher compared to those of the HS (p < 0.05, p < 0.05). From these results, O. humifusa supplementation might play an important role for improving insulin sensitivity through elevation of PPAR-γ, PGC-1α, and GLUT-4 protein expression in rat skeletal muscle.
Keywords: O. humifusa; insulin sensitivity; PPAR-γ; PGC-1α; GLUT-4 O. humifusa; insulin sensitivity; PPAR-γ; PGC-1α; GLUT-4
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kang, J.; Lee, J.; Kwon, D.; Song, Y. Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats. Int. J. Mol. Sci. 2013, 14, 7140-7154.

AMA Style

Kang J, Lee J, Kwon D, Song Y. Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats. International Journal of Molecular Sciences. 2013; 14(4):7140-7154.

Chicago/Turabian Style

Kang, Junyong; Lee, Junghun; Kwon, Daekeun; Song, Youngju. 2013. "Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats." Int. J. Mol. Sci. 14, no. 4: 7140-7154.



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