Int. J. Mol. Sci. 2013, 14(2), 3834-3859; doi:10.3390/ijms14023834
Review

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

1,2,* email, 3,4email and 3email
Received: 2 January 2013; in revised form: 25 January 2013 / Accepted: 29 January 2013 / Published: 11 February 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Increased oxidative stress has been associated with the aging process. However, recent studies have revealed that a low-level oxidative stress can even extend the lifespan of organisms. Reactive oxygen species (ROS) are important signaling molecules, e.g., being required for autophagic degradation. SIRT1, a class III protein deacetylase, is a crucial cellular survival protein, which is also involved in combatting oxidative stress. For instance, SIRT1 can stimulate the expression of antioxidants via the FoxO pathways. Moreover, in contrast to ROS, SIRT1 inhibits NF-κB signaling which is a major inducer of inflammatory responses, e.g., with inflammasome pathway. Recent studies have demonstrated that an increased level of ROS can both directly and indirectly control the activity of SIRT1 enzyme. For instance, ROS can inhibit SIRT1 activity by evoking oxidative modifications on its cysteine residues. Decreased activity of SIRT1 enhances the NF-κB signaling, which supports inflammatory responses. This crosstalk between the SIRT1 and ROS signaling provokes in a context-dependent manner a decline in autophagy and a low-grade inflammatory phenotype, both being common hallmarks of ageing. We will review the major mechanisms controlling the signaling balance between the ROS production and SIRT1 activity emphasizing that this crosstalk has a crucial role in the regulation of the aging process.
Keywords: ageing; autophagy; oxidative stress; inflammasome; NF-κB; ROS; SIRT1
PDF Full-text Download PDF Full-Text [249 KB, uploaded 19 June 2014 04:43 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Salminen, A.; Kaarniranta, K.; Kauppinen, A. Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int. J. Mol. Sci. 2013, 14, 3834-3859.

AMA Style

Salminen A, Kaarniranta K, Kauppinen A. Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. International Journal of Molecular Sciences. 2013; 14(2):3834-3859.

Chicago/Turabian Style

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. 2013. "Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process." Int. J. Mol. Sci. 14, no. 2: 3834-3859.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert