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Synthesis and Characterization of the Inclusion Complex of β-cyclodextrin and Azomethine
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
* Author to whom correspondence should be addressed.
Received: 8 December 2012; in revised form: 14 January 2013 / Accepted: 25 January 2013 / Published: 7 February 2013
Abstract: A β-cyclodextrin (β-Cyd) inclusion complex containing azomethine as a guest was prepared by kneading method with aliquot addition of ethanol. The product was characterized by Fourier Transform Infrared (FTIR) spectrometer, 1H Nuclear Magnetic Resonance (1H NMR) and Thermogravimetric Analyzer (TGA), which proves the formation of the inclusion complex where the benzyl part of azomethine has been encapsulated by the hydrophobic cavity of β-Cyd. The interaction of β-Cyd and azomethine was also analyzed by means of spectrometry by UV-Vis spectrophotometer to determine the formation constant. The formation constant was calculated by using a modified Benesi-Hildebrand equation at 25 °C. The apparent formation constant obtained was 1.29 × 104 L/mol. Besides that, the stoichiometry ratio was also determined to be 1:1 for the inclusion complex of β-Cyd with azomethine.
Keywords: β-cyclodextrin; azomethine; Schiff bases; inclusion complex
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Sambasevam, K.P.; Mohamad, S.; Sarih, N.M.; Ismail, N.A. Synthesis and Characterization of the Inclusion Complex of β-cyclodextrin and Azomethine. Int. J. Mol. Sci. 2013, 14, 3671-3682.
Sambasevam KP, Mohamad S, Sarih NM, Ismail NA. Synthesis and Characterization of the Inclusion Complex of β-cyclodextrin and Azomethine. International Journal of Molecular Sciences. 2013; 14(2):3671-3682.
Sambasevam, Kavirajaa P.; Mohamad, Sharifah; Sarih, Norazilawati M.; Ismail, Nor A. 2013. "Synthesis and Characterization of the Inclusion Complex of β-cyclodextrin and Azomethine." Int. J. Mol. Sci. 14, no. 2: 3671-3682.