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Int. J. Mol. Sci. 2013, 14(2), 3487-3499; doi:10.3390/ijms14023487

Increased Placental Phospholipid Levels in Pre-Eclamptic Pregnancies

1 Institute of Biochemistry and Molecular Medicine, University of Bern, Bern 3012, Switzerland 2 Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, Bern 3012, Switzerland 3 Department of Obstetrics and Gynecology, University Hospital, University of Bern, Bern 3010, Switzerland 4 Institute of Pathology, University of Bern, Bern 3010, Switzerland These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 17 December 2012 / Revised: 22 January 2013 / Accepted: 30 January 2013 / Published: 6 February 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Physiological pregnancy is associated with an increase in lipids from the first to the third trimester. This is a highly regulated response to satisfy energy and membrane demands of the developing fetus. Pregnancy disorders, such as pre-eclampsia, are associated with a dysregulation of lipid metabolism manifesting in increased maternal plasma lipid levels. In fetal placental tissue, only scarce information on the lipid profile is available, and data for gestational diseases are lacking. In the present study, we investigated the placental lipid content in control versus pre-eclamptic samples, with the focus on tissue phospholipid levels and composition. We found an increase in total phospholipid content as well as changes in individual phospholipid classes in pre-eclamptic placental tissues compared to controls. These alterations could be a source of placental pathological changes in pre-eclampsia, such as lipid peroxide insult or dysregulation of lipid transport across the syncytiotrophoblast.
Keywords: phospholipids; pre-eclampsia; placenta phospholipids; pre-eclampsia; placenta
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, X.; Jain, A.; Baumann, M.; Körner, M.; Surbek, D.; Bütikofer, P.; Albrecht, C. Increased Placental Phospholipid Levels in Pre-Eclamptic Pregnancies. Int. J. Mol. Sci. 2013, 14, 3487-3499.

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