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Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice
Department of Pharmacology, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China
Shandong Provincial Key Laboratory of Chemical Drug, Shandong Institute of Pharmaceutical Industry, Xinluo Road 989, Jinan 250101, China
Department of Pharmacy, Zhangqiu People's Hospital, Huiquan Road 1920, Zhangqiu 250200, China
Shandong Hongjitang Pharmaceutical Group Co., Ltd., Hualong Road 360, Jinan 250100, China
* Author to whom correspondence should be addressed.
Received: 14 October 2013; in revised form: 22 November 2013 / Accepted: 25 November 2013 / Published: 9 December 2013
Abstract: The present study evaluated the anti-inflammatory effects of 4-methylcyclopentadecanone (4-MCPC) on edema models in mice and aimed to determine the safety of 4-MCPC after acute exposure. The acute toxicity of 4-MCPC was evaluated by oral administration to rats of single doses of 0, 5, 50, 500 and 5000 mg/kg. Toxic symptoms were observed for 14 days. The anti-inflammatory activity was evaluated in xylene-induced mouse ear edema and carrageenan-induced mouse paw edema. The animals were treated with 4-MCPC once every day for seven consecutive days. Edema index, % inhibition, IL-1β, TNF-α, PGE2 and MPO levels in paws were detected after the treatment with xylene or carrageenan. Our results indicated that the LD50 value of 4-MCPC in rats is greater than 5000 mg/kg. The ED50 of 4-MCPC in xylene-induced mouse ear edema model was 7.5 mg/kg. 4-MCPC (8 or 16 mg/kg) remarkably inhibited carrageenan-induced mouse paw edema. Further study revealed that 4-MCPC treatment also decreased IL-1β, TNF-α, PGE2 and MPO levels in mice paws. Intragastric administration of 4-MCPC exhibited more significant anti-inflammatory activity than muscone at a dose of 16 mg/kg. Taken together, our results suggest that 4-MCPC has potent anti-inflammatory activity and the mechanisms might be related to the decreases of the levels of IL-1β, TNF-α, PGE2 and MPO in inflamed paws.
Keywords: 4-methylcyclopentadecanone; inflammation; paw edema; ear edema; toxicity
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Ma, Y.; Li, Y.; Li, X.; Wu, Y. Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice. Int. J. Mol. Sci. 2013, 14, 23980-23992.
Ma Y, Li Y, Li X, Wu Y. Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice. International Journal of Molecular Sciences. 2013; 14(12):23980-23992.
Ma, Yukui; Li, Yue; Li, Xiufeng; Wu, Yingliang. 2013. "Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice." Int. J. Mol. Sci. 14, no. 12: 23980-23992.