Int. J. Mol. Sci. 2013, 14(12), 23980-23992; doi:10.3390/ijms141223980
Article

Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice

1,2email, 3email, 4email and 1,* email
1 Department of Pharmacology, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China 2 Shandong Provincial Key Laboratory of Chemical Drug, Shandong Institute of Pharmaceutical Industry, Xinluo Road 989, Jinan 250101, China 3 Department of Pharmacy, Zhangqiu People's Hospital, Huiquan Road 1920, Zhangqiu 250200, China 4 Shandong Hongjitang Pharmaceutical Group Co., Ltd., Hualong Road 360, Jinan 250100, China
* Author to whom correspondence should be addressed.
Received: 14 October 2013; in revised form: 22 November 2013 / Accepted: 25 November 2013 / Published: 9 December 2013
(This article belongs to the Section Molecular Pathology)
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Abstract: The present study evaluated the anti-inflammatory effects of 4-methylcyclopentadecanone (4-MCPC) on edema models in mice and aimed to determine the safety of 4-MCPC after acute exposure. The acute toxicity of 4-MCPC was evaluated by oral administration to rats of single doses of 0, 5, 50, 500 and 5000 mg/kg. Toxic symptoms were observed for 14 days. The anti-inflammatory activity was evaluated in xylene-induced mouse ear edema and carrageenan-induced mouse paw edema. The animals were treated with 4-MCPC once every day for seven consecutive days. Edema index, % inhibition, IL-1β, TNF-α, PGE2 and MPO levels in paws were detected after the treatment with xylene or carrageenan. Our results indicated that the LD50 value of 4-MCPC in rats is greater than 5000 mg/kg. The ED50 of 4-MCPC in xylene-induced mouse ear edema model was 7.5 mg/kg. 4-MCPC (8 or 16 mg/kg) remarkably inhibited carrageenan-induced mouse paw edema. Further study revealed that 4-MCPC treatment also decreased IL-1β, TNF-α, PGE2 and MPO levels in mice paws. Intragastric administration of 4-MCPC exhibited more significant anti-inflammatory activity than muscone at a dose of 16 mg/kg. Taken together, our results suggest that 4-MCPC has potent anti-inflammatory activity and the mechanisms might be related to the decreases of the levels of IL-1β, TNF-α, PGE2 and MPO in inflamed paws.
Keywords: 4-methylcyclopentadecanone; inflammation; paw edema; ear edema; toxicity

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MDPI and ACS Style

Ma, Y.; Li, Y.; Li, X.; Wu, Y. Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice. Int. J. Mol. Sci. 2013, 14, 23980-23992.

AMA Style

Ma Y, Li Y, Li X, Wu Y. Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice. International Journal of Molecular Sciences. 2013; 14(12):23980-23992.

Chicago/Turabian Style

Ma, Yukui; Li, Yue; Li, Xiufeng; Wu, Yingliang. 2013. "Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice." Int. J. Mol. Sci. 14, no. 12: 23980-23992.

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