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Int. J. Mol. Sci. 2013, 14(12), 23492-23498; doi:10.3390/ijms141223492

Verifiable Hypotheses for Thymosin β4-Dependent and -Independent Angiogenic Induction of Trichinella spiralis-Triggered Nurse Cell Formation

1
Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 602-702, Korea
2
Institute for Medical Science, Kosin University College of Medicine, Busan 602-702, Korea
3
Department of Biochemistry, College of Oriental Medicine, Anti-Aging Research Center, Dongeui University, Busan 614-052, Korea
*
Authors to whom correspondence should be addressed.
Received: 28 October 2013 / Revised: 22 November 2013 / Accepted: 22 November 2013 / Published: 29 November 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Trichinella spiralis has been reported to induce angiogenesis for nutrient supply and waste disposal by the induction of the angiogenic molecule vascular endothelial cell growth factor (VEGF) during nurse cell formation. However, the action mechanism to induce VEGF in nurse cells by T. spiralis is not known. Hypoxia in nurse cells was suggested as a possible mechanism; however, the presence of hypoxic conditions in infected muscle or nurse cells and whether hypoxia indeed induces the expression of VEGF and subsequent angiogenesis in the infected muscle are both a matter of debate. Our recent studies have shown that thymosin β4, a potent VEGF inducing protein, is expressed in the very early stages of T. spiralis muscle infection suggesting the induction of VEGF in early stage nurse cells. Nevertheless, we now show that hypoxic conditions were not detected in any nurse cell stage but were detected only in the accumulated inflammatory cells. These studies propose that induction of angiogenesis by VEGF in T. spiralis-infected nurse cells was mediated by thymosin β4 and is unrelated to hypoxic conditions. View Full-Text
Keywords: thymosin β4; Trichinella spiralis; nurse cells; angiogenesis; hypoxia thymosin β4; Trichinella spiralis; nurse cells; angiogenesis; hypoxia
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ock, M.S.; Cha, H.-J.; Choi, Y.H. Verifiable Hypotheses for Thymosin β4-Dependent and -Independent Angiogenic Induction of Trichinella spiralis-Triggered Nurse Cell Formation. Int. J. Mol. Sci. 2013, 14, 23492-23498.

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