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Possible Role of −374T/A Polymorphism of RAGE Gene in Longevity
Interdepartimental Center for Research in Molecular Medicine (CIRMC), University of Pavia, Via Taramelli 24, Pavia 27100, Italy
Department of Cardiology, Istituiti Clinici di Pavia e Vigevano University Hospital, Via Parco Vecchio 27, Pavia 27100, Italy
IRCCS San Donato Hospital, San Donato Milanese 20097, Italy
* Author to whom correspondence should be addressed.
Received: 9 October 2013; in revised form: 11 November 2013 / Accepted: 15 November 2013 / Published: 21 November 2013
Abstract: Demographic and social changes in the last decades have resulted in improvements in health and longevity. The survival of elderly people has improved significantly and thus centenarians are becoming the fastest growing population group. Environmental, genetic, and accidental factors have influenced the human life span. Researchers have gained substantial evidence that advanced glycation end products may play an important role in the processes of physiological aging. The aim of the present study was to investigate any differences in the frequencies of −374T/A polymorphism in subjects aged >90 years and in middle-aged individuals. We observed association between the A allele and genotype homozygous for this allele (AA) with a longer life expectancy in the male population. In particular, there was a prevalence of AA genotype and A allele in long-living subjects and a prevalence of the allele T in middle-aged subjects, indicating a possible protective role of the allele A to aging. In conclusion, our results support the hypothesis that longevity is the result of a good functioning of the immune system and a presumable hyper-expression of variants of anti-inflammatory genes of immunity. The differences in the genetic regulation of inflammatory processes may influence the presence of age-related disorders.
Keywords: receptor for advanced glycation end products; −374T/A polymorphisms; longevity
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Falcone, C.; Bozzini, S.; Colonna, A.; Matrone, B.; Paganini, E.M.; Falcone, R.; Pelissero, G. Possible Role of −374T/A Polymorphism of RAGE Gene in Longevity. Int. J. Mol. Sci. 2013, 14, 23203-23211.
Falcone C, Bozzini S, Colonna A, Matrone B, Paganini EM, Falcone R, Pelissero G. Possible Role of −374T/A Polymorphism of RAGE Gene in Longevity. International Journal of Molecular Sciences. 2013; 14(11):23203-23211.
Falcone, Colomba; Bozzini, Sara; Colonna, Anna; Matrone, Benedetta; Paganini, Edoardo M.; Falcone, Rossana; Pelissero, Gabriele. 2013. "Possible Role of −374T/A Polymorphism of RAGE Gene in Longevity." Int. J. Mol. Sci. 14, no. 11: 23203-23211.