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Int. J. Mol. Sci. 2013, 14(11), 21887-21898; doi:10.3390/ijms141121887
Article

The Anti-Fasciolasis Properties of Silver Nanoparticles Produced by Trichoderma harzianum and Their Improvement of the Anti-Fasciolasis Drug Triclabendazole

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Received: 22 September 2013; in revised form: 21 October 2013 / Accepted: 28 October 2013 / Published: 5 November 2013
(This article belongs to the Special Issue Bioactive Nanoparticles 2013)
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Abstract: Recently, new strains of Fasciola demonstrated drug resistance, which increased the need for new drugs or improvement of the present drugs. Nanotechnology is expected to open some new opportunities to fight and prevent diseases using an atomic scale tailoring of materials. The ability to uncover the structure and function of biosystems at the nanoscale, stimulates research leading to improvement in biology, biotechnology, medicine and healthcare. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications. Therefore, this work aimed to isolate fungal strains from Taif soil samples, which have the ability to synthesize silver nanoparticles. The fungus Trichoderma harzianum, when challenged with silver nitrate solution, accumulated silver nanoparticles (AgNBs) on the surface of its cell wall in 72 h. These nanoparticles, dislodged by ultrasonication, showed an absorption peak at 420 nm in a UV-visible spectrum, corresponding to the plasmon resonance of silver nanoparticles. The transmission electron micrographs of dislodged nanoparticles in aqueous solution showed the production of reasonably monodisperse silver nanoparticles (average particle size: 4.66 nm) by the fungus. The percentage of non hatching eggs treated with the Triclabendazole drug was 69.67%, while this percentage increased to 89.67% in combination with drug and AgNPs.
Keywords: egg hatching; Fasciola; silver nanoparticle; Triclabendazole; Trichoderma egg hatching; Fasciola; silver nanoparticle; Triclabendazole; Trichoderma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gherbawy, Y.A.; Shalaby, I.M.; El-sadek, M.S.A.; Elhariry, H.M.; Banaja, A.A. The Anti-Fasciolasis Properties of Silver Nanoparticles Produced by Trichoderma harzianum and Their Improvement of the Anti-Fasciolasis Drug Triclabendazole. Int. J. Mol. Sci. 2013, 14, 21887-21898.

AMA Style

Gherbawy YA, Shalaby IM, El-sadek MSA, Elhariry HM, Banaja AA. The Anti-Fasciolasis Properties of Silver Nanoparticles Produced by Trichoderma harzianum and Their Improvement of the Anti-Fasciolasis Drug Triclabendazole. International Journal of Molecular Sciences. 2013; 14(11):21887-21898.

Chicago/Turabian Style

Gherbawy, Youssuf A.; Shalaby, Ismail M.; El-sadek, Mahmoud S.A.; Elhariry, Hesham M.; Banaja, AbdelElah A. 2013. "The Anti-Fasciolasis Properties of Silver Nanoparticles Produced by Trichoderma harzianum and Their Improvement of the Anti-Fasciolasis Drug Triclabendazole." Int. J. Mol. Sci. 14, no. 11: 21887-21898.



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