Int. J. Mol. Sci. 2013, 14(11), 21598-21612; doi:10.3390/ijms141121598
Article

The Effect of Different Intensities of Treadmill Exercise on Cognitive Function Deficit Following a Severe Controlled Cortical Impact in Rats

1,3,†email, 2,†,* email, 1email, 2email, 1email, 1email, 1email and 1email
Received: 30 August 2013; in revised form: 12 October 2013 / Accepted: 17 October 2013 / Published: 31 October 2013
(This article belongs to the Section Molecular Recognition)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Exercise has been proposed for the treatment of traumatic brain injury (TBI). However, the proper intensity of exercise in the early phase following a severe TBI is largely unknown. To compare two different treadmill exercise intensities on the cognitive function following a severe TBI in its early phase, rats experienced a controlled cortical impact (CCI) and were forced to treadmill exercise for 14 days. The results revealed that the rats in the low intensity exercise group had a shorter latency to locate a platform and a significantly better improvement in spatial memory in the Morris water maze (MWM) compared to the control group (p < 0.05). The high intensity exercise group showed a longer latency and a mild improvement in spatial memory compared to the control group rats in the MWM; however, this difference was not statistically significant (p > 0.05). The brain-derived neurotrophic factor (BDNF) and p-CREB protein levels in the contralateral hippocampus were increased significantly in the low intensity exercise group. Our results suggest that 2 weeks of low intensity of treadmill exercise is beneficial for improving cognitive function and increasing hippocampal BDNF expression after a severe TBI in its early phase.
Keywords: controlled cortical impact; treadmill running; spatial memory; intensity; BDNF
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MDPI and ACS Style

Shen, X.; Li, A.; Zhang, Y.; Dong, X.; Shan, T.; Wu, Y.; Jia, J.; Hu, Y. The Effect of Different Intensities of Treadmill Exercise on Cognitive Function Deficit Following a Severe Controlled Cortical Impact in Rats. Int. J. Mol. Sci. 2013, 14, 21598-21612.

AMA Style

Shen X, Li A, Zhang Y, Dong X, Shan T, Wu Y, Jia J, Hu Y. The Effect of Different Intensities of Treadmill Exercise on Cognitive Function Deficit Following a Severe Controlled Cortical Impact in Rats. International Journal of Molecular Sciences. 2013; 14(11):21598-21612.

Chicago/Turabian Style

Shen, Xiafeng; Li, Aiping; Zhang, Yuling; Dong, XiaoMin; Shan, Tian; Wu, Yi; Jia, Jie; Hu, Yongshan. 2013. "The Effect of Different Intensities of Treadmill Exercise on Cognitive Function Deficit Following a Severe Controlled Cortical Impact in Rats." Int. J. Mol. Sci. 14, no. 11: 21598-21612.

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