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Int. J. Mol. Sci. 2013, 14(11), 21463-21473; doi:10.3390/ijms141121463
Article

Imbalance between Th17 and Regulatory T-Cells in Sarcoidosis

1,†
, 2,†
, 1
, 1
, 1
 and 1,*
Received: 27 May 2013; in revised form: 18 October 2013 / Accepted: 23 October 2013 / Published: 30 October 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Sarcoidosis is a systemic granulomatous disease, which is thought to result from an aberrant immune response. CD4+ T lymphocytes play an important role in the development of granulomas. Previously, the immunopathogenesis of sarcoidosis was focused on Th1/Th2 disturbances. The aim of this study was to evaluate the balance between newer CD4+ T lymphocytes, i.e., Treg and Th17 cells. In our studies, a decrease in Treg cells and an increase in Th17 cells were observed in the peripheral blood and BALF of sarcoidosis patients. A significant increase in the Th17/Treg cell ratio was observed in sarcoidosis patients. After treatment with prednisone, the expression of Foxp3 mRNA was elevated in the peripheral blood, and expression of (ROR)γt mRNA showed a downward trend. These findings suggest that sarcoidosis is associated with an imbalance between Th17 and Treg cells in peripheral blood and BALF. Therefore, targeting the cytokines that affect the Th17/Treg ratio could provide a new promising therapy for pulmonary sarcoidosis.
Keywords: granulomatous disease; sarcoidosis; regulatory T cells; Th17 cells; corticosteroids granulomatous disease; sarcoidosis; regulatory T cells; Th17 cells; corticosteroids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, H.; Lu, Z.; Jiang, C.; Liu, J.; Wang, Y.; Xu, Z. Imbalance between Th17 and Regulatory T-Cells in Sarcoidosis. Int. J. Mol. Sci. 2013, 14, 21463-21473.

AMA Style

Huang H, Lu Z, Jiang C, Liu J, Wang Y, Xu Z. Imbalance between Th17 and Regulatory T-Cells in Sarcoidosis. International Journal of Molecular Sciences. 2013; 14(11):21463-21473.

Chicago/Turabian Style

Huang, Hui; Lu, Zhiwei; Jiang, Chunguo; Liu, Jia; Wang, Yanxun; Xu, Zuojun. 2013. "Imbalance between Th17 and Regulatory T-Cells in Sarcoidosis." Int. J. Mol. Sci. 14, no. 11: 21463-21473.


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