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Int. J. Mol. Sci. 2013, 14(10), 21071-21086; doi:10.3390/ijms141021071
Review

Angiotensin-Converting Enzymes Play a Dominant Role in Fertility

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Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China
* Author to whom correspondence should be addressed.
Received: 10 August 2013 / Revised: 14 October 2013 / Accepted: 14 October 2013 / Published: 21 October 2013
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Abstract

According to the World Health Organization, infertility, associated with metabolic syndrome, has become a global issue with a 10%–20% incidence worldwide. An accumulating body of evidence has shown that the renin–angiotensin system is involved in the fertility problems observed in some populations. Moreover, alterations in the expression of angiotensin-converting enzyme-1, angiotensin-converting enzyme-2, and angiotensin-converting enzyme-3 might be one of the most important mechanisms underlying both female and male infertility. However, as a pseudogene in humans, further studies are needed to explore whether the abnormal angiotensin-converting enzyme-3 gene could result in the problems of human reproduction. In this review, the relationship between angiotensin-converting enzymes and fertile ability is summarized, and a new procedure for the treatment of infertility is discussed.
Keywords: angiotensin-converting enzyme; fertility; metabolic syndrome; renin-angiotensin system; angiotensin-converting enzyme inhibitor angiotensin-converting enzyme; fertility; metabolic syndrome; renin-angiotensin system; angiotensin-converting enzyme inhibitor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pan, P.-P.; Zhan, Q.-T.; Le, F.; Zheng, Y.-M.; Jin, F. Angiotensin-Converting Enzymes Play a Dominant Role in Fertility. Int. J. Mol. Sci. 2013, 14, 21071-21086.

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