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Int. J. Mol. Sci. 2013, 14(10), 21071-21086; doi:10.3390/ijms141021071
Review

Angiotensin-Converting Enzymes Play a Dominant Role in Fertility

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Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China
* Author to whom correspondence should be addressed.
Received: 10 August 2013 / Revised: 14 October 2013 / Accepted: 14 October 2013 / Published: 21 October 2013
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Abstract

According to the World Health Organization, infertility, associated with metabolic syndrome, has become a global issue with a 10%–20% incidence worldwide. An accumulating body of evidence has shown that the renin–angiotensin system is involved in the fertility problems observed in some populations. Moreover, alterations in the expression of angiotensin-converting enzyme-1, angiotensin-converting enzyme-2, and angiotensin-converting enzyme-3 might be one of the most important mechanisms underlying both female and male infertility. However, as a pseudogene in humans, further studies are needed to explore whether the abnormal angiotensin-converting enzyme-3 gene could result in the problems of human reproduction. In this review, the relationship between angiotensin-converting enzymes and fertile ability is summarized, and a new procedure for the treatment of infertility is discussed.
Keywords: angiotensin-converting enzyme; fertility; metabolic syndrome; renin-angiotensin system; angiotensin-converting enzyme inhibitor angiotensin-converting enzyme; fertility; metabolic syndrome; renin-angiotensin system; angiotensin-converting enzyme inhibitor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pan, P.-P.; Zhan, Q.-T.; Le, F.; Zheng, Y.-M.; Jin, F. Angiotensin-Converting Enzymes Play a Dominant Role in Fertility. Int. J. Mol. Sci. 2013, 14, 21071-21086.

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