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Int. J. Mol. Sci. 2013, 14(10), 20890-20912; doi:10.3390/ijms141020890

Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing

College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Author to whom correspondence should be addressed.
Received: 29 August 2013 / Revised: 20 September 2013 / Accepted: 8 October 2013 / Published: 17 October 2013
(This article belongs to the Special Issue Glycosylation and Glycoproteins)
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Glycoproteins influence a broad spectrum of biological processes including cell-cell interaction, host-pathogen interaction, or protection of proteins against proteolytic degradation. The analysis of their glyco-structures and concentration levels are increasingly important in diagnosis and proteomics. Boronic acids can covalently react with cis-diols in the oligosaccharide chains of glycoproteins to form five- or six-membered cyclic esters. Based on this interaction, boronic acid-based ligands and materials have attracted much attention in both chemistry and biology as the recognition motif for enrichment and chemo/biosensing of glycoproteins in recent years. In this work, we reviewed the progress in the separation, immobilization and detection of glycoproteins with boronic acid-functionalized materials and addressed its application in sensing.
Keywords: glycoproteins; boronic acid; separation; sensing glycoproteins; boronic acid; separation; sensing
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, X.; Xia, N.; Liu, L. Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing. Int. J. Mol. Sci. 2013, 14, 20890-20912.

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