Int. J. Mol. Sci. 2013, 14(10), 20890-20912; doi:10.3390/ijms141020890
Review

Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing

College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
* Author to whom correspondence should be addressed.
Received: 29 August 2013; in revised form: 20 September 2013 / Accepted: 8 October 2013 / Published: 17 October 2013
(This article belongs to the Special Issue Glycosylation and Glycoproteins)
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Abstract: Glycoproteins influence a broad spectrum of biological processes including cell-cell interaction, host-pathogen interaction, or protection of proteins against proteolytic degradation. The analysis of their glyco-structures and concentration levels are increasingly important in diagnosis and proteomics. Boronic acids can covalently react with cis-diols in the oligosaccharide chains of glycoproteins to form five- or six-membered cyclic esters. Based on this interaction, boronic acid-based ligands and materials have attracted much attention in both chemistry and biology as the recognition motif for enrichment and chemo/biosensing of glycoproteins in recent years. In this work, we reviewed the progress in the separation, immobilization and detection of glycoproteins with boronic acid-functionalized materials and addressed its application in sensing.
Keywords: glycoproteins; boronic acid; separation; sensing

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MDPI and ACS Style

Wang, X.; Xia, N.; Liu, L. Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing. Int. J. Mol. Sci. 2013, 14, 20890-20912.

AMA Style

Wang X, Xia N, Liu L. Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing. International Journal of Molecular Sciences. 2013; 14(10):20890-20912.

Chicago/Turabian Style

Wang, Xiaojin; Xia, Ning; Liu, Lin. 2013. "Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing." Int. J. Mol. Sci. 14, no. 10: 20890-20912.

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