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Int. J. Mol. Sci. 2013, 14(10), 19526-19539; doi:10.3390/ijms141019526
Article

Synthesis and Activity of Novel Acylthiourea with Hydantoin

1
, 1
, 1,2
, 1
 and 1,*
1 Department of Applied Chemistry, China Agricultural University, Beijing 100193, China 2 College of Agricuture, Yangtze University, Jingzhou 434025, Hubei, China
* Author to whom correspondence should be addressed.
Received: 23 July 2013 / Revised: 29 August 2013 / Accepted: 18 September 2013 / Published: 26 September 2013
(This article belongs to the Section Bioinorganic Chemistry)
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Abstract

The 41 novel acylthiourea derivatives with hydantoin were synthesized in moderate to excellent yields by using 5-(4-aminophenyl)- and 5-(4-aminobenzyl)-hydantoin or 5-(4-aminobenzyl)-thiohydantoin as raw materials and characterized by IR, 1H NMR spectra and elementary analysis. The preliminary bioassay showed that these compounds exhibit certain selectively herbicidal activities with the 91%, 94% and 87% inhibition rates of 7l, 8o and 8p against B. campestris, 100%, 100% and 95% efficacy against B. campestris in a greenhouse test, respectively. 7a, 7b, 7c and 7d exhibited 74%, 79%, 79% and 71% inhibition rates against F. oxysporum, respectively.
Keywords: acylthiourea; hydantoin; thiohydantoin; herbicidal activity; fungicidal activity acylthiourea; hydantoin; thiohydantoin; herbicidal activity; fungicidal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Han, J.; Dong, H.; Xu, Z.; Wang, J.; Wang, M. Synthesis and Activity of Novel Acylthiourea with Hydantoin. Int. J. Mol. Sci. 2013, 14, 19526-19539.

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