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An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases
Department of Pharmacology, School of Medicine, Chonbuk National Univeristy, Jeonju 561-180, South Korea
Department of Dental Pharmacology, Dental School, Wonkwang University, Iksan 570-749, South Korea
* Authors to whom correspondence should be addressed.
Received: 26 October 2012; in revised form: 1 December 2012 / Accepted: 13 December 2012 / Published: 24 December 2012
Abstract: The endoplasmic reticulum (ER) is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to the predominant disulfide bond formation during the process of protein folding. Alterations in the oxidative environment of the ER and also intra-ER Ca2+ cause the production of ER stress-induced reactive oxygen species (ROS). Protein disulfide isomerases, endoplasmic reticulum oxidoreductin-1, reduced glutathione and mitochondrial electron transport chain proteins also play crucial roles in ER stress-induced production of ROS. In this article, we discuss ER stress-associated ROS and related diseases, and the current understanding of the signaling transduction involved in ER stress.
Keywords: ER stress; ER stress associated disease; ER associated oxidative stress; disulfide bond formation; PDI; ERO-1α; mitochondria electron transport chain
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Bhandary, B.; Marahatta, A.; Kim, H.-R.; Chae, H.-J. An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases. Int. J. Mol. Sci. 2013, 14, 434-456.
Bhandary B, Marahatta A, Kim H-R, Chae H-J. An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases. International Journal of Molecular Sciences. 2013; 14(1):434-456.
Bhandary, Bidur; Marahatta, Anu; Kim, Hyung-Ryong; Chae, Han-Jung. 2013. "An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases." Int. J. Mol. Sci. 14, no. 1: 434-456.