Next Article in Journal
Role of Carnitine Acetyl Transferase in Regulation of Nitric Oxide Signaling in Pulmonary Arterial Endothelial Cells
Previous Article in Journal
The Controversial Role of Retinoic Acid in Fibrotic Diseases: Analysis of Involved Signaling Pathways
Int. J. Mol. Sci. 2013, 14(1), 244-254; doi:10.3390/ijms14010244
Article

Nano Size Effects of TiO2 Nanotube Array on the Glioma Cells Behavior

1,†
,
2,†
,
2,* , 2
,
1
 and
2,*
1 Liaoning Provincial Universities Key Laboratory of Boron Resource Ecological Utilization Technology and Boron Materials, Northeastern University, No.11, Lane 3, Wenhua Road, Heping District, Shenyang 110819, China 2 Departments of Neurosurgery, The First Affiliated Hospital of China Medical University, 155 Nanjingbei Street, Heping District, Shenyang 110001, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 4 September 2012 / Revised: 26 November 2012 / Accepted: 11 December 2012 / Published: 21 December 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [559 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

In order to investigate the interplay between the cells and TiO2 nanotube array, and to explore the ability of cells to sense the size change in nano-environment, we reported on the behavior of glioma C6 cells on nanotube array coatings in terms of proliferation and apoptosis. The behavior of glioma C6 cells was obviously size-dependent on the coatings; the caliber with 15 nm diameter provided effective spacing to improve the cells proliferation and enhanced the cellular activities. C6 cells’ biological behaviors showed many similar tendencies to many phorocytes; the matching degree of geometry between nanotube and integrin defined that a spacing of 15 nm was optimal for inducing signals to nucleus, which results in achieving maximum activity of glioma cells. In addition, the immune behavior of cells was studied, a variety of inflammatory mediator’s gene expression levels were controlled by the nanoscale dimension, the expressions of IL-6 and IL-10 were higher on 30 nm than on 15 nm nanotube.
Keywords: nanotube; glioma cells; proliferation; inflammatory mediator’s gene; signal channel nanotube; glioma cells; proliferation; inflammatory mediator’s gene; signal channel
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Yang, H.; Qin, X.; Tian, A.; Zhang, D.; Xue, X.; Wu, A. Nano Size Effects of TiO2 Nanotube Array on the Glioma Cells Behavior. Int. J. Mol. Sci. 2013, 14, 244-254.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert