Abstract: In order to investigate the interplay between the cells and TiO2 nanotube array, and to explore the ability of cells to sense the size change in nano-environment, we reported on the behavior of glioma C6 cells on nanotube array coatings in terms of proliferation and apoptosis. The behavior of glioma C6 cells was obviously size-dependent on the coatings; the caliber with 15 nm diameter provided effective spacing to improve the cells proliferation and enhanced the cellular activities. C6 cells’ biological behaviors showed many similar tendencies to many phorocytes; the matching degree of geometry between nanotube and integrin defined that a spacing of 15 nm was optimal for inducing signals to nucleus, which results in achieving maximum activity of glioma cells. In addition, the immune behavior of cells was studied, a variety of inflammatory mediator’s gene expression levels were controlled by the nanoscale dimension, the expressions of IL-6 and IL-10 were higher on 30 nm than on 15 nm nanotube.
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Yang, H.; Qin, X.; Tian, A.; Zhang, D.; Xue, X.; Wu, A. Nano Size Effects of TiO2 Nanotube Array on the Glioma Cells Behavior. Int. J. Mol. Sci. 2013, 14, 244-254.
Yang H, Qin X, Tian A, Zhang D, Xue X, Wu A. Nano Size Effects of TiO2 Nanotube Array on the Glioma Cells Behavior. International Journal of Molecular Sciences. 2013; 14(1):244-254.
Yang, He; Qin, Xiaofei; Tian, Ang; Zhang, Dongyong; Xue, Xiangxin; Wu, Anhua. 2013. "Nano Size Effects of TiO2 Nanotube Array on the Glioma Cells Behavior." Int. J. Mol. Sci. 14, no. 1: 244-254.