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Biofunctional Constituents from Liriodendron tulipifera with Antioxidants and Anti-Melanogenic Properties
Bachelor Degree Program of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 25 October 2012; in revised form: 16 December 2012 / Accepted: 4 January 2013 / Published: 15 January 2013
Abstract: From the stems of Liriodendron tulipifera, seventeen known compounds have been extracted, isolated and purified. By using spectroscopic analysis, the structures of these pure constituents were determined as three lignans, four steroids and ten benzenoids. Identified compounds were screened for antioxidant abilities using: 1,1-diphenyl-2-picrylhydrazul (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging free radical activity assays; metal chelating power test; and ferric reducing/antioxidant power (FRAP) examination. The result revealed that seventeen compounds had potential anti-oxidative capabilities. In addition, the anti-tyrosinase effect was determined by calculating the hydroxylation of L-tyrosine to L-dopa and the oxidization of L-dopa to dopaquinone, according to in vitro mushroom tyrosinase evaluation platform. Furthermore, based on assays on B16F10 cell line, our data suggest that five compounds isolated from L. tulipifera would be able to inhibit tyrosinase activity and reduce the melanin content in animal cells. Therefore, some of the examined compounds could be potentially used in the cosmetic skin whitening business, therapeutic applications or the food industry.
Keywords: Liriodendron tulipifera; antioxidant; tyrosinase inhibitor; B16F10
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Li, W.-J.; Lin, Y.-C.; Wu, P.-F.; Wen, Z.-H.; Liu, P.-L.; Chen, C.-Y.; Wang, H.-M. Biofunctional Constituents from Liriodendron tulipifera with Antioxidants and Anti-Melanogenic Properties. Int. J. Mol. Sci. 2013, 14, 1698-1712.
Li W-J, Lin Y-C, Wu P-F, Wen Z-H, Liu P-L, Chen C-Y, Wang H-M. Biofunctional Constituents from Liriodendron tulipifera with Antioxidants and Anti-Melanogenic Properties. International Journal of Molecular Sciences. 2013; 14(1):1698-1712.
Li, Wei-Jen; Lin, Yi-Chieh; Wu, Pei-Fang; Wen, Zhi-Hong; Liu, Po-Len; Chen, Chung-Yi; Wang, Hui-Min. 2013. "Biofunctional Constituents from Liriodendron tulipifera with Antioxidants and Anti-Melanogenic Properties." Int. J. Mol. Sci. 14, no. 1: 1698-1712.