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Int. J. Mol. Sci. 2012, 13(9), 11705-11717; doi:10.3390/ijms130911705
Review

Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways

1,* , 2
, 1
 and 1
Received: 4 July 2012; in revised form: 31 August 2012 / Accepted: 3 September 2012 / Published: 18 September 2012
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer 2012)
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Abstract: Ovarian cancer is the most lethal gynecologic malignancy. Despite advances in chemotherapy, the five-year survival rate of advanced ovarian cancer patients with peritoneal metastasis remains around 30%. The most significant prognostic factor is stage, and most patients present at an advanced stage with peritoneal dissemination. There is often no clearly identifiable precursor lesion; therefore, the events leading to metastatic disease are poorly understood. This article reviews metastatic suppressor genes, the epithelial-mesenchymal transition (EMT), and the tumor microenvironment as they relate to ovarian cancer metastasis. Additionally, novel chemotherapeutic agents targeting the metastasis-related biochemical pathways are discussed.
Keywords: cancer; metastasis suppressor gene; EMT; tumor microenvironment cancer; metastasis suppressor gene; EMT; tumor microenvironment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nakayama, K.; Nakayama, N.; Katagiri, H.; Miyazaki, K. Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways. Int. J. Mol. Sci. 2012, 13, 11705-11717.

AMA Style

Nakayama K, Nakayama N, Katagiri H, Miyazaki K. Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways. International Journal of Molecular Sciences. 2012; 13(9):11705-11717.

Chicago/Turabian Style

Nakayama, Kentaro; Nakayama, Naomi; Katagiri, Hiroshi; Miyazaki, Kohji. 2012. "Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways." Int. J. Mol. Sci. 13, no. 9: 11705-11717.


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