Next Article in Journal
Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
Next Article in Special Issue
The Heterochromatic Barrier to DNA Double Strand Break Repair: How to Get the Entry Visa
Previous Article in Journal
α-Tocopherol at Nanomolar Concentration Protects PC12 Cells from Hydrogen Peroxide-Induced Death and Modulates Protein Kinase Activities
Previous Article in Special Issue
Nucleotide Excision Repair in Cellular Chromatin: Studies with Yeast from Nucleotide to Gene to Genome
Int. J. Mol. Sci. 2012, 13(9), 11569-11583; doi:10.3390/ijms130911569
Review

Is DNA Damage Response Ready for Action Anywhere?

* ,
,
,
 and
Received: 31 July 2012; in revised form: 6 September 2012 / Accepted: 7 September 2012 / Published: 14 September 2012
View Full-Text   |   Download PDF [1259 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability.
Keywords: micronuclei; DSB repair; NER pathway; chromosome instability micronuclei; DSB repair; NER pathway; chromosome instability
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Terradas, M.; Martín, M.; Hernández, L.; Tusell, L.; Genescà, A. Is DNA Damage Response Ready for Action Anywhere? Int. J. Mol. Sci. 2012, 13, 11569-11583.

AMA Style

Terradas M, Martín M, Hernández L, Tusell L, Genescà A. Is DNA Damage Response Ready for Action Anywhere? International Journal of Molecular Sciences. 2012; 13(9):11569-11583.

Chicago/Turabian Style

Terradas, Mariona; Martín, Marta; Hernández, Laia; Tusell, Laura; Genescà, Anna. 2012. "Is DNA Damage Response Ready for Action Anywhere?" Int. J. Mol. Sci. 13, no. 9: 11569-11583.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert