Int. J. Mol. Sci. 2012, 13(9), 11569-11583; doi:10.3390/ijms130911569

Is DNA Damage Response Ready for Action Anywhere?

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Received: 31 July 2012; in revised form: 6 September 2012 / Accepted: 7 September 2012 / Published: 14 September 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability.
Keywords: micronuclei; DSB repair; NER pathway; chromosome instability
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MDPI and ACS Style

Terradas, M.; Martín, M.; Hernández, L.; Tusell, L.; Genescà, A. Is DNA Damage Response Ready for Action Anywhere? Int. J. Mol. Sci. 2012, 13, 11569-11583.

AMA Style

Terradas M, Martín M, Hernández L, Tusell L, Genescà A. Is DNA Damage Response Ready for Action Anywhere? International Journal of Molecular Sciences. 2012; 13(9):11569-11583.

Chicago/Turabian Style

Terradas, Mariona; Martín, Marta; Hernández, Laia; Tusell, Laura; Genescà, Anna. 2012. "Is DNA Damage Response Ready for Action Anywhere?" Int. J. Mol. Sci. 13, no. 9: 11569-11583.

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