Next Article in Journal
Effects of Sorafenib on C-Terminally Truncated Androgen Receptor Variants in Human Prostate Cancer Cells
Previous Article in Journal
Characterization of Erysiphe necator-Responsive Genes in Chinese Wild Vitis quinquangularis
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2012, 13(9), 11520-11529; doi:10.3390/ijms130911520

New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew

Department of Pharmacy, Abdul Wali Khan University Mardan, Anbar Campus 23200, Pakistan
Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan
Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat 2600, Pakistan
Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan
H.E.J. Research Institute of Chemistry, International Center for Chemical and biological Sciences, University of Karachi, Karachi 75270, Pakistan
Department of Pharmaceutical and Biomedical Sciences, Universiy of Salerno, Salerno 84100, Italy
Author to whom correspondence should be addressed.
Received: 26 July 2012 / Revised: 29 August 2012 / Accepted: 30 August 2012 / Published: 14 September 2012
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [281 KB, uploaded 19 June 2014]   |  


Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 µg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 µg/mL), Pseudomonas aeruginosa (MIC, 50 µg/mL) and Salmonella typhi (MIC, 50 µg/mL). View Full-Text
Keywords: Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kaleem, W.A.; Nisar, M.; Qayum, M.; Zia-Ul-Haq, M.; Adhikari, A.; De Feo, V. New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew. Int. J. Mol. Sci. 2012, 13, 11520-11529.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top