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Int. J. Mol. Sci. 2012, 13(9), 11520-11529; doi:10.3390/ijms130911520
Article

New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew

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Received: 26 July 2012 / Revised: 29 August 2012 / Accepted: 30 August 2012 / Published: 14 September 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 µg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 µg/mL), Pseudomonas aeruginosa (MIC, 50 µg/mL) and Salmonella typhi (MIC, 50 µg/mL).
Keywords: Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kaleem, W.A.; Nisar, M.; Qayum, M.; Zia-Ul-Haq, M.; Adhikari, A.; De Feo, V. New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew. Int. J. Mol. Sci. 2012, 13, 11520-11529.

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