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New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
Department of Pharmacy, Abdul Wali Khan University Mardan, Anbar Campus 23200, Pakistan
Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan
Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat 2600, Pakistan
Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan
H.E.J. Research Institute of Chemistry, International Center for Chemical and biological Sciences, University of Karachi, Karachi 75270, Pakistan
Department of Pharmaceutical and Biomedical Sciences, Universiy of Salerno, Salerno 84100, Italy
* Author to whom correspondence should be addressed.
Received: 26 July 2012; in revised form: 29 August 2012 / Accepted: 30 August 2012 / Published: 14 September 2012
Abstract: Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 µg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 µg/mL), Pseudomonas aeruginosa (MIC, 50 µg/mL) and Salmonella typhi (MIC, 50 µg/mL).
Keywords: Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity
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Kaleem, W.A.; Nisar, M.; Qayum, M.; Zia-Ul-Haq, M.; Adhikari, A.; De Feo, V. New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew. Int. J. Mol. Sci. 2012, 13, 11520-11529.
Kaleem WA, Nisar M, Qayum M, Zia-Ul-Haq M, Adhikari A, De Feo V. New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew. International Journal of Molecular Sciences. 2012; 13(9):11520-11529.
Kaleem, Waqar Ahmad; Nisar, Muhammad; Qayum, Mughal; Zia-Ul-Haq, Muhammad; Adhikari, Achyut; De Feo, Vincenzo. 2012. "New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew." Int. J. Mol. Sci. 13, no. 9: 11520-11529.