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Int. J. Mol. Sci. 2012, 13(9), 11520-11529; doi:10.3390/ijms130911520
Article

New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew

1
, 2
, 3
, 4
, 5
 and 6,*
1 Department of Pharmacy, Abdul Wali Khan University Mardan, Anbar Campus 23200, Pakistan 2 Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan 3 Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat 2600, Pakistan 4 Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan 5 H.E.J. Research Institute of Chemistry, International Center for Chemical and biological Sciences, University of Karachi, Karachi 75270, Pakistan 6 Department of Pharmaceutical and Biomedical Sciences, Universiy of Salerno, Salerno 84100, Italy
* Author to whom correspondence should be addressed.
Received: 26 July 2012 / Revised: 29 August 2012 / Accepted: 30 August 2012 / Published: 14 September 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 µg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 µg/mL), Pseudomonas aeruginosa (MIC, 50 µg/mL) and Salmonella typhi (MIC, 50 µg/mL).
Keywords: Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kaleem, W.A.; Nisar, M.; Qayum, M.; Zia-Ul-Haq, M.; Adhikari, A.; De Feo, V. New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew. Int. J. Mol. Sci. 2012, 13, 11520-11529.

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