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Int. J. Mol. Sci. 2012, 13(9), 11520-11529; doi:10.3390/ijms130911520
Article

New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew

1
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2
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 and
6,*
1 Department of Pharmacy, Abdul Wali Khan University Mardan, Anbar Campus 23200, Pakistan 2 Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan 3 Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat 2600, Pakistan 4 Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan 5 H.E.J. Research Institute of Chemistry, International Center for Chemical and biological Sciences, University of Karachi, Karachi 75270, Pakistan 6 Department of Pharmaceutical and Biomedical Sciences, Universiy of Salerno, Salerno 84100, Italy
* Author to whom correspondence should be addressed.
Received: 26 July 2012 / Revised: 29 August 2012 / Accepted: 30 August 2012 / Published: 14 September 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 µg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 µg/mL), Pseudomonas aeruginosa (MIC, 50 µg/mL) and Salmonella typhi (MIC, 50 µg/mL).
Keywords: Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kaleem, W.A.; Nisar, M.; Qayum, M.; Zia-Ul-Haq, M.; Adhikari, A.; De Feo, V. New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew. Int. J. Mol. Sci. 2012, 13, 11520-11529.

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