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Int. J. Mol. Sci. 2012, 13(9), 11194-11209; doi:10.3390/ijms130911194

Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels

*  and
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
* Author to whom correspondence should be addressed.
Received: 29 June 2012 / Revised: 10 August 2012 / Accepted: 20 August 2012 / Published: 10 September 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Four novel hydrogels based on chitosan were synthesized via a cross-linking reaction of chitosan with different concentrations of oxalyl bis 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)benzamide. Their structures were confirmed by fourier transform infrared X-ray (FTIR), scanning electron microscopy (SEM) and X-ray diffraction. The antimicrobial activities of the hydrogels against two crop-threatening pathogenic fungi namely: Aspergillus fumigatus (A. fumigatus, RCMBA 06002), and Aspergillus niger (A. niger, RCMBA 06106), and five bacterial species namely: Bacillis subtilis (B. subtilis, RCMBA 6005), Staphylococcus aureus (S. aureus, RCMBA 2004), Streptococcus pneumoniae (S. pneumonia, RCMB 000101) as Gram positive bacteria, and Salmonella typhimurium (S. typhimurium, RCMB 000104), and Escherichia coli (E. coli, RCMBA 5003) as Gram negative bacteria have been investigated. The prepared hydrogels showed much higher antimicrobial activities than that of the parent chitosan. The hydrogels were more potent in case of Gram-positive bacteria than Gram-negative bacteria. Increasing the degree of cross-linking in the hydrogels resulted in a weaker antimicrobial activity.
Keywords: chitosan; chemical cross-linking; hydrogels; antimicrobial activity chitosan; chemical cross-linking; hydrogels; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mohamed, N.A.; Fahmy, M.M. Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels. Int. J. Mol. Sci. 2012, 13, 11194-11209.

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