Int. J. Mol. Sci. 2012, 13(9), 11194-11209; doi:10.3390/ijms130911194

Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
* Author to whom correspondence should be addressed.
Received: 29 June 2012; in revised form: 10 August 2012 / Accepted: 20 August 2012 / Published: 10 September 2012
(This article belongs to the Section Material Sciences and Nanotechnology)
PDF Full-text Download PDF Full-Text [1013 KB, Updated Version, uploaded 11 September 2012 14:50 CEST]
The original version is still available [1168 KB, uploaded 10 September 2012 13:31 CEST]
Abstract: Four novel hydrogels based on chitosan were synthesized via a cross-linking reaction of chitosan with different concentrations of oxalyl bis 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)benzamide. Their structures were confirmed by fourier transform infrared X-ray (FTIR), scanning electron microscopy (SEM) and X-ray diffraction. The antimicrobial activities of the hydrogels against two crop-threatening pathogenic fungi namely: Aspergillus fumigatus (A. fumigatus, RCMBA 06002), and Aspergillus niger (A. niger, RCMBA 06106), and five bacterial species namely: Bacillis subtilis (B. subtilis, RCMBA 6005), Staphylococcus aureus (S. aureus, RCMBA 2004), Streptococcus pneumoniae (S. pneumonia, RCMB 000101) as Gram positive bacteria, and Salmonella typhimurium (S. typhimurium, RCMB 000104), and Escherichia coli (E. coli, RCMBA 5003) as Gram negative bacteria have been investigated. The prepared hydrogels showed much higher antimicrobial activities than that of the parent chitosan. The hydrogels were more potent in case of Gram-positive bacteria than Gram-negative bacteria. Increasing the degree of cross-linking in the hydrogels resulted in a weaker antimicrobial activity.
Keywords: chitosan; chemical cross-linking; hydrogels; antimicrobial activity

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Mohamed, N.A.; Fahmy, M.M. Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels. Int. J. Mol. Sci. 2012, 13, 11194-11209.

AMA Style

Mohamed NA, Fahmy MM. Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels. International Journal of Molecular Sciences. 2012; 13(9):11194-11209.

Chicago/Turabian Style

Mohamed, Nadia Ahmed; Fahmy, Mona Mohamed. 2012. "Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels." Int. J. Mol. Sci. 13, no. 9: 11194-11209.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert