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Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
* Author to whom correspondence should be addressed.
Received: 29 June 2012; in revised form: 10 August 2012 / Accepted: 20 August 2012 / Published: 10 September 2012
Abstract: Four novel hydrogels based on chitosan were synthesized via a cross-linking reaction of chitosan with different concentrations of oxalyl bis 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)benzamide. Their structures were confirmed by fourier transform infrared X-ray (FTIR), scanning electron microscopy (SEM) and X-ray diffraction. The antimicrobial activities of the hydrogels against two crop-threatening pathogenic fungi namely: Aspergillus fumigatus (A. fumigatus, RCMBA 06002), and Aspergillus niger (A. niger, RCMBA 06106), and five bacterial species namely: Bacillis subtilis (B. subtilis, RCMBA 6005), Staphylococcus aureus (S. aureus, RCMBA 2004), Streptococcus pneumoniae (S. pneumonia, RCMB 000101) as Gram positive bacteria, and Salmonella typhimurium (S. typhimurium, RCMB 000104), and Escherichia coli (E. coli, RCMBA 5003) as Gram negative bacteria have been investigated. The prepared hydrogels showed much higher antimicrobial activities than that of the parent chitosan. The hydrogels were more potent in case of Gram-positive bacteria than Gram-negative bacteria. Increasing the degree of cross-linking in the hydrogels resulted in a weaker antimicrobial activity.
Keywords: chitosan; chemical cross-linking; hydrogels; antimicrobial activity
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MDPI and ACS Style
Mohamed, N.A.; Fahmy, M.M. Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels. Int. J. Mol. Sci. 2012, 13, 11194-11209.
Mohamed NA, Fahmy MM. Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels. International Journal of Molecular Sciences. 2012; 13(9):11194-11209.
Mohamed, Nadia Ahmed; Fahmy, Mona Mohamed. 2012. "Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels." Int. J. Mol. Sci. 13, no. 9: 11194-11209.