Next Article in Journal
Activation of Propane C-H and C-C Bonds by Gas-Phase Pt Atom: A Theoretical Study
Previous Article in Journal
Enhancing Oxidative Stability of Sunflower Oil during Convective and Microwave Heating Using Grape Seed Extract
Int. J. Mol. Sci. 2012, 13(7), 9260-9277; doi:10.3390/ijms13079260
Article

Correlation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extract

1,* , 2
,
2
,
2
,
3
,
4 and 1
Received: 20 April 2012 / Revised: 15 July 2012 / Accepted: 20 July 2012 / Published: 24 July 2012
View Full-Text   |   Download PDF [1382 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

The biological activities of a plant extract depend on a complex sum of individual properties including the antioxidant activity. Several biological activities protect against the harmful action of reactive oxygen species (ROS), and here we focused our attention on the relationship between the biological activities tested and the antioxidant properties. In this study, the total flavonoid content as well as the antioxidant, antimicrobial, hemolytic and cytotoxicity activities of the methanolic extract of Leitothrix spiralis leaves were evaluated. The extract showed a total flavonoid content of 19.26% and the chemical characterization by HPLC-PAD confirmed the presence of flavonoids as the major secondary metabolite compounds. Significant antioxidant activity (IC50 = 1.743 µg/mL ± 0.063) was demonstrated and was effective against Gram-negative organisms and all Candida strains tested, and showed an ability to inhibit hyphal formation. Non-hemolytic and antiproliferative activity could be demonstrated.
Keywords: Leiothrix spiralis; luteolin; antioxidant; antimicrobial; hemolytic; citotoxicity Leiothrix spiralis; luteolin; antioxidant; antimicrobial; hemolytic; citotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

de Freitas Araújo, M.G.; Hilário, F.; Vilegas, W.; dos Santos, L.C.; Brunetti, I.L.; Sotomayor, C.E.; Bauab, T.M. Correlation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extract. Int. J. Mol. Sci. 2012, 13, 9260-9277.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert