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Int. J. Mol. Sci. 2012, 13(7), 9260-9277; doi:10.3390/ijms13079260

Correlation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extract

1
Biological Sciences Department, Faculty of Pharmaceutical Sciences, São Paulo State University—UNESP, Araraquara, SP 14801-902, Brazil
2
Organic Chemistry Department, Chemistry Institute, São Paulo State University—UNESP, c.p. 355, Araraquara, SP 14800-900, Brazil
3
Clinical Analysis Department, Faculty of Pharmaceutical Sciences, São Paulo State University—UNESP, Araraquara, SP 14801-902, Brazil
4
Department of Clinical Biochemistry, CIBICI-CONICET, Faculty of Chemical Sciences, National University of Cordoba, Haya de la Torre y Medina Allende, Córdoba 5000, Argentina
*
Author to whom correspondence should be addressed.
Received: 20 April 2012 / Revised: 15 July 2012 / Accepted: 20 July 2012 / Published: 24 July 2012
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Abstract

The biological activities of a plant extract depend on a complex sum of individual properties including the antioxidant activity. Several biological activities protect against the harmful action of reactive oxygen species (ROS), and here we focused our attention on the relationship between the biological activities tested and the antioxidant properties. In this study, the total flavonoid content as well as the antioxidant, antimicrobial, hemolytic and cytotoxicity activities of the methanolic extract of Leitothrix spiralis leaves were evaluated. The extract showed a total flavonoid content of 19.26% and the chemical characterization by HPLC-PAD confirmed the presence of flavonoids as the major secondary metabolite compounds. Significant antioxidant activity (IC50 = 1.743 µg/mL ± 0.063) was demonstrated and was effective against Gram-negative organisms and all Candida strains tested, and showed an ability to inhibit hyphal formation. Non-hemolytic and antiproliferative activity could be demonstrated.
Keywords: Leiothrix spiralis; luteolin; antioxidant; antimicrobial; hemolytic; citotoxicity Leiothrix spiralis; luteolin; antioxidant; antimicrobial; hemolytic; citotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

de Freitas Araújo, M.G.; Hilário, F.; Vilegas, W.; dos Santos, L.C.; Brunetti, I.L.; Sotomayor, C.E.; Bauab, T.M. Correlation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extract. Int. J. Mol. Sci. 2012, 13, 9260-9277.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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