Next Article in Journal
Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites
Previous Article in Journal
Density Functional Theory (DFT) Study of Edaravone Derivatives as Antioxidants
Article Menu

Export Article

Open AccessCommunication
Int. J. Mol. Sci. 2012, 13(6), 7607-7616; doi:10.3390/ijms13067607

Ultrasound-Assisted Extraction of Syringin from the Bark of Ilex rotunda Thumb Using Response Surface Methodology

1
College of Pharmacy, Hebei University, Baoding 071002, China
2
The Affiliated Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530011, China
3
College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
4
China-Japan Union Hospital, Jilin University, Changchun 130033, China
*
Authors to whom correspondence should be addressed.
Received: 28 April 2012 / Revised: 12 May 2012 / Accepted: 15 May 2012 / Published: 20 June 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [690 KB, uploaded 19 June 2014]   |  

Abstract

In this work, a rapid extraction method based on ultrasound-assisted extraction (UAE) of syringin from the bark of Ilex rotunda Thumb using response surface methodology (RSM) is described. The syringin was analyzed and quantified by high performance liquid chromatography coupled with UV detection (HPLC-UV). The extraction solvent, extraction temperature and extraction time, the three main factors for UAE, were optimized with Box-Behnken design (BBD) to obtain the highest extraction efficiency. The optimal conditions were the use of a sonication frequency of 40 kHz, 65% methanol as the solvent, an extraction time of 30 min and an extraction temperature of 40 °C. Using these optimal conditions, the experimental values agreed closely with the predicted values. The analysis of variance (ANOVA) indicated a high goodness of model fit and the success of the RSM method for optimizing syringin extraction from the bark of I. rotunda. View Full-Text
Keywords: ultrasound-assisted extraction; syringin; Ilex rotunda; response surface methodology; Box-Behnken design ultrasound-assisted extraction; syringin; Ilex rotunda; response surface methodology; Box-Behnken design
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhao, L.-C.; He, Y.; Deng, X.; Xia, X.-H.; Liang, J.; Yang, G.-L.; Li, W.; Wang, H. Ultrasound-Assisted Extraction of Syringin from the Bark of Ilex rotunda Thumb Using Response Surface Methodology. Int. J. Mol. Sci. 2012, 13, 7607-7616.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top