Next Article in Journal
Phages and HIV-1: From Display to Interplay
Previous Article in Journal
Effect of Calcium Sprays on Mechanical Strength and Cell Wall Fractions of Herbaceous Peony (Paeonia Lactiflora Pall.) Inflorescence Stems
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2012, 13(4), 4714-4726; doi:10.3390/ijms13044714

Frequent Gene Amplification Predicts Poor Prognosis in Gastric Cancer

1
Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an 710061, China
2
Department of Surgery, The First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an 710061, China
3
State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
4
Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an 710061, China
*
Authors to whom correspondence should be addressed.
Received: 13 March 2012 / Revised: 26 March 2012 / Accepted: 30 March 2012 / Published: 13 April 2012
View Full-Text   |   Download PDF [390 KB, uploaded 19 June 2014]   |  

Abstract

Gastric cancer is one of the most common malignancies worldwide. However, genetic alterations leading to this disease are largely unknown. Gene amplification is one of the most frequent genetic alterations, which is believed to play a major role in the development and progression of gastric cancer. In the present study, we identified three frequently amplified genes from 30 candidate genes using real-time quantitative PCR method, including ERBB4, C-MET and CD44, and further explored their association with clinicopathological characteristics and poor survival in a cohort of gastric cancers. Our data showed amplification of these genes was significantly associated with certain clinicopathological characteristics, particularly tumor differentiation and cancer-related death. More importantly, amplification of these genes was significantly related to worse survival, suggesting that these amplified genes may be significant predictors of poor prognosis and potential therapeutic targets in gastric cancer. Targeting these genes may thus provide new possibilities in the treatment of gastric cancer. View Full-Text
Keywords: gastric cancer; oncogenes; gene amplification; poor prognosis gastric cancer; oncogenes; gene amplification; poor prognosis
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shi, J.; Yao, D.; Liu, W.; Wang, N.; Lv, H.; He, N.; Shi, B.; Hou, P.; Ji, M. Frequent Gene Amplification Predicts Poor Prognosis in Gastric Cancer. Int. J. Mol. Sci. 2012, 13, 4714-4726.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top