Biochemistry of Bacterial Multidrug Efflux Pumps
AbstractBacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps.
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Kumar, S.; Varela, M.F. Biochemistry of Bacterial Multidrug Efflux Pumps. Int. J. Mol. Sci. 2012, 13, 4484-4495.
Kumar S, Varela MF. Biochemistry of Bacterial Multidrug Efflux Pumps. International Journal of Molecular Sciences. 2012; 13(4):4484-4495.Chicago/Turabian Style
Kumar, Sanath; Varela, Manuel F. 2012. "Biochemistry of Bacterial Multidrug Efflux Pumps." Int. J. Mol. Sci. 13, no. 4: 4484-4495.