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Int. J. Mol. Sci. 2012, 13(4), 4484-4495; doi:10.3390/ijms13044484

Biochemistry of Bacterial Multidrug Efflux Pumps

QC Laboratory, Post Harvest Technology Department, Central Institute of Fisheries Education (CIFE), Versova, Mumbai 400061 India
Biology Department, Eastern New Mexico University, Portales New Mexico, 88130, USA
Author to whom correspondence should be addressed.
Received: 24 February 2012 / Revised: 9 March 2012 / Accepted: 15 March 2012 / Published: 10 April 2012
(This article belongs to the Special Issue Membrane Transport)
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Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps.
Keywords: efflux pump; antibiotic resistance; MFS; antiporter; Tet; Qac efflux pump; antibiotic resistance; MFS; antiporter; Tet; Qac
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kumar, S.; Varela, M.F. Biochemistry of Bacterial Multidrug Efflux Pumps. Int. J. Mol. Sci. 2012, 13, 4484-4495.

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