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Int. J. Mol. Sci. 2012, 13(4), 4484-4495; doi:10.3390/ijms13044484

Review

Biochemistry of Bacterial Multidrug Efflux Pumps

Sanath Kumar ¹  and Manuel F. Varela ^2,*

¹ QC Laboratory, Post Harvest Technology Department, Central Institute of Fisheries Education (CIFE), Versova, Mumbai 400061 India ² Biology Department, Eastern New Mexico University, Portales New Mexico, 88130, USA

* Author to whom correspondence should be addressed.

Received: 24 February 2012; in revised form: 9 March 2012 / Accepted: 15 March 2012 / Published: 10 April 2012

(This article belongs to the Special Issue Membrane Transport)

Download PDF Full-Text [213 KB, uploaded 10 April 2012 10:27 CEST]

Abstract: Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps.

Keywords: efflux pump; antibiotic resistance; MFS; antiporter; Tet; Qac

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