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Production of Protocatechuic Acid in Bacillus Thuringiensis ATCC33679
Department of Biology, Tougaloo College, Tougaloo, MS 39174, USA
Center for Bioinformatics and Computational Biology, Department of Biology, Jackson State University, Jackson, MS 39217, USA
* Author to whom correspondence should be addressed.
Received: 29 January 2012; in revised form: 16 March 2012 / Accepted: 19 March 2012 / Published: 21 March 2012
Abstract: Protocatechuic acid, or 3,4-dihydroxybenzoic acid, is produced by both soil and marine bacteria in the free form and as the iron binding component of the siderophore petrobactin. The soil bacterium, Bacillus thuringiensis kurstaki ATCC 33679, contains the asb operon, but does not produce petrobactin. Iron restriction resulted in diminished B. thuringiensis kurstaki ATCC 33679 growth and the production of catechol(s). The gene product responsible for protocatechuic acid (asbF) and its receptor (fatB) were expressed during stationary phase growth. Gene expression varied with growth temperature, with optimum levels occurring well below the Bacillus anthracis virulence temperature of 37 °C. Regulation of protocatechuic acid suggests a possible role for this compound during soil growth cycles.
Keywords: catechol; Bacillus; protocatechuic acid
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MDPI and ACS Style
Williams, K.M.; Martin, W.E.; Smith, J.; Williams, B.S.; Garner, B.L. Production of Protocatechuic Acid in Bacillus Thuringiensis ATCC33679. Int. J. Mol. Sci. 2012, 13, 3765-3772.
Williams KM, Martin WE, Smith J, Williams BS, Garner BL. Production of Protocatechuic Acid in Bacillus Thuringiensis ATCC33679. International Journal of Molecular Sciences. 2012; 13(3):3765-3772.
Williams, Kimtrele M.; Martin, William E.; Smith, Justin; Williams, Baraka S.; Garner, Bianca L. 2012. "Production of Protocatechuic Acid in Bacillus Thuringiensis ATCC33679." Int. J. Mol. Sci. 13, no. 3: 3765-3772.