Int. J. Mol. Sci. 2012, 13(3), 3661-3670; doi:10.3390/ijms13033661
Article

Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety

1 Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt 2 On leave to Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, P. O. Box 418 Abha 61431, Saudi Arabia 3 Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455 Riyadh 11451, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 16 January 2012; in revised form: 7 March 2012 / Accepted: 13 March 2012 / Published: 19 March 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: The synthetic utility of 3,3’-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a–g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.
Keywords: thieno[2,3-b]thiophene; nucleophilic addition; hydrazonoyl halides; bis-thiadiazoles; bis-thiazoles; antimicrobial activity

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MDPI and ACS Style

Kheder, N.A.; Mabkhot, Y.N. Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety. Int. J. Mol. Sci. 2012, 13, 3661-3670.

AMA Style

Kheder NA, Mabkhot YN. Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety. International Journal of Molecular Sciences. 2012; 13(3):3661-3670.

Chicago/Turabian Style

Kheder, Nabila Abdelshafy; Mabkhot, Yahia Nasser. 2012. "Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety." Int. J. Mol. Sci. 13, no. 3: 3661-3670.

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