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Int. J. Mol. Sci. 2012, 13(3), 3661-3670; doi:10.3390/ijms13033661
Article

Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety

1,2
 and 3,*
1 Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt 2 On leave to Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, P. O. Box 418 Abha 61431, Saudi Arabia 3 Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455 Riyadh 11451, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 16 January 2012 / Revised: 7 March 2012 / Accepted: 13 March 2012 / Published: 19 March 2012
(This article belongs to the Section Bioinorganic Chemistry)
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Abstract

The synthetic utility of 3,3’-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a–g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.
Keywords: thieno[2,3-b]thiophene; nucleophilic addition; hydrazonoyl halides; bis-thiadiazoles; bis-thiazoles; antimicrobial activity thieno[2,3-b]thiophene; nucleophilic addition; hydrazonoyl halides; bis-thiadiazoles; bis-thiazoles; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kheder, N.A.; Mabkhot, Y.N. Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety. Int. J. Mol. Sci. 2012, 13, 3661-3670.

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