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Int. J. Mol. Sci. 2012, 13(3), 3661-3670; doi:10.3390/ijms13033661
Article

Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety

1,2
 and
3,*
Received: 16 January 2012 / Revised: 7 March 2012 / Accepted: 13 March 2012 / Published: 19 March 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The synthetic utility of 3,3’-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a–g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.
Keywords: thieno[2,3-b]thiophene; nucleophilic addition; hydrazonoyl halides; bis-thiadiazoles; bis-thiazoles; antimicrobial activity thieno[2,3-b]thiophene; nucleophilic addition; hydrazonoyl halides; bis-thiadiazoles; bis-thiazoles; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kheder, N.A.; Mabkhot, Y.N. Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety. Int. J. Mol. Sci. 2012, 13, 3661-3670.

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