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Heat Shock Protein 90 in Plants: Molecular Mechanisms and Roles in Stress Responses
Institute of Crop Science, Chinese Academy of Agricultural Sciences (CAAS)/National Key Facility for Crop Gene Resources and Genetic Improvement, Key Laboratory of Biology and Genetic Improvement of Triticeae Crops, Ministry of Agriculture, Beijing 100081, China
* Author to whom correspondence should be addressed.
Received: 28 September 2012; in revised form: 29 October 2012 / Accepted: 29 October 2012 / Published: 23 November 2012
Abstract: The heat shock protein 90 (Hsp90) family mediates stress signal transduction, and plays important roles in the control of normal growth of human cells and in promoting development of tumor cells. Hsp90s have become a currently important subject in cellular immunity, signal transduction, and anti-cancer research. Studies on the physiological functions of Hsp90s began much later in plants than in animals and fungi. Significant progress has been made in understanding complex mechanisms of HSP90s in plants, including ATPase-coupled conformational changes and interactions with cochaperone proteins. A wide range of signaling proteins interact with HSP90s. Recent studies revealed that plant Hsp90s are important in plant development, environmental stress response, and disease and pest resistance. In this study, the plant HSP90 family was classified into three clusters on the basis of phylogenetic relationships, gene structure, and biological functions. We discuss the molecular functions of Hsp90s, and systematically review recent progress of Hsp90 research in plants.
Keywords: plant Hsp90; interaction mechanism; disease resistance; abiotic stress tolerance; phylogenetic relationship
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Xu, Z.-S.; Li, Z.-Y.; Chen, Y.; Chen, M.; Li, L.-C.; Ma, Y.-Z. Heat Shock Protein 90 in Plants: Molecular Mechanisms and Roles in Stress Responses. Int. J. Mol. Sci. 2012, 13, 15706-15723.
Xu Z-S, Li Z-Y, Chen Y, Chen M, Li L-C, Ma Y-Z. Heat Shock Protein 90 in Plants: Molecular Mechanisms and Roles in Stress Responses. International Journal of Molecular Sciences. 2012; 13(12):15706-15723.
Xu, Zhao-Shi; Li, Zhi-Yong; Chen, Yang; Chen, Ming; Li, Lian-Cheng; Ma, You-Zhi. 2012. "Heat Shock Protein 90 in Plants: Molecular Mechanisms and Roles in Stress Responses." Int. J. Mol. Sci. 13, no. 12: 15706-15723.