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Int. J. Mol. Sci. 2012, 13(1), 466-476; doi:10.3390/ijms13010466

Fungus-Mediated Green Synthesis of Silver Nanoparticles Using Aspergillus terreus

Department of Pathogenobiology, Norman Bethune College of Medicine, Jilin University Mycology Research Center, Jilin University, Changchun 130021, China
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China
Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan
Author to whom correspondence should be addressed.
Received: 8 November 2011 / Revised: 23 November 2011 / Accepted: 15 December 2011 / Published: 29 December 2011
(This article belongs to the Section Green Chemistry)
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The biosynthesis of nanoparticles has received increasing attention due to the growing need to develop safe, cost-effective and environmentally friendly technologies for nano-materials synthesis. In this report, silver nanoparticles (AgNPs) were synthesized using a reduction of aqueous Ag+ ion with the culture supernatants of Aspergillus terreus. The reaction occurred at ambient temperature and in a few hours. The bioreduction of AgNPs was monitored by ultraviolet-visible spectroscopy, and the AgNPs obtained were characterized by transmission electron microscopy and X-ray diffraction. The synthesized AgNPs were polydispersed spherical particles ranging in size from 1 to 20 nm and stabilized in the solution. Reduced nicotinamide adenine dinucleotide (NADH) was found to be an important reducing agent for the biosynthesis, and the formation of AgNPs might be an enzyme-mediated extracellular reaction process. Furthermore, the antimicrobial potential of AgNPs was systematically evaluated. The synthesized AgNPs could efficiently inhibit various pathogenic organisms, including bacteria and fungi. The current research opens a new avenue for the green synthesis of nano-materials.
Keywords: silver nanoparticles; Aspergillus terreus; biosynthesis; NADH silver nanoparticles; Aspergillus terreus; biosynthesis; NADH
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, G.; He, D.; Qian, Y.; Guan, B.; Gao, S.; Cui, Y.; Yokoyama, K.; Wang, L. Fungus-Mediated Green Synthesis of Silver Nanoparticles Using Aspergillus terreus. Int. J. Mol. Sci. 2012, 13, 466-476.

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