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Int. J. Mol. Sci. 2011, 12(9), 6135-6145; doi:10.3390/ijms12096135
Article

Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice

1,2,†,* , 3,†
 and 4
Received: 3 August 2011; in revised form: 25 August 2011 / Accepted: 13 September 2011 / Published: 20 September 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: The current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-induced diabetic mice. The diabetic mice were randomly divided into four groups (8 mice per group): diabetic control group, low-dose Gl-PS treated group (50 mg/kg, Gl-PS), high-dose Gl-PS treated group (150 mg/kg, Gl-PS) and positive drug control treated group (glibenclamide, 4 mg/kg), with normal mice used as the control group. Body weights, fasting blood glucose (FBG), serum insulin and blood lipid levels of mice were measured. After 28 days of treatment with Gl-PS, body weights and serum insulin levels of the Gl-PS treated groups was significantly higher than that of the diabetic control group , whereas FBG levels was significantly lower. Moreover, total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels of the Gl-PS treated groups had dropped, whereas the high density lipoprotein cholesterol (HDL-C) levels had increased. In addition, according to acute toxicity studies, Gl-PS did not cause behavioral changes and any death of mice. These data suggest that Gl-PS has an antihyperglycemic effect. Furthermore, considering the Gl-PS effects on lipid profile, it may be a potential hypolipidaemic agent, which will be a great advantage in treating diabetic conditions associated with atherosclerosis or hyperlipidemia.
Keywords: antihyperglycemic; ganoderma lucidum polysaccharides; streptozotocin; diabetic mice antihyperglycemic; ganoderma lucidum polysaccharides; streptozotocin; diabetic mice
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, F.; Zhang, Y.; Zhong, Z. Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice. Int. J. Mol. Sci. 2011, 12, 6135-6145.

AMA Style

Li F, Zhang Y, Zhong Z. Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice. International Journal of Molecular Sciences. 2011; 12(9):6135-6145.

Chicago/Turabian Style

Li, Fenglin; Zhang, Yiming; Zhong, Zhijian. 2011. "Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice." Int. J. Mol. Sci. 12, no. 9: 6135-6145.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert