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Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice
Department of Bioengineering, Collage of Jilin Agricultural Science and Technology, Jilin 132101, Jilin, China
College of Enviroment & Chemical Engineering, Yanshan University, Qinhuangdao 066400, Hebei, China
Department of Plastic, Cosmetic and Reconstructive Surgery, Xinqiao Hospital, Chongqing 400037, China
Department of Arctic and Marine Biology, Faculty of Biosciences, Fisheries and Economics, University of Troms, Troms 9037, Norway
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 3 August 2011; in revised form: 25 August 2011 / Accepted: 13 September 2011 / Published: 20 September 2011
Abstract: The current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-induced diabetic mice. The diabetic mice were randomly divided into four groups (8 mice per group): diabetic control group, low-dose Gl-PS treated group (50 mg/kg, Gl-PS), high-dose Gl-PS treated group (150 mg/kg, Gl-PS) and positive drug control treated group (glibenclamide, 4 mg/kg), with normal mice used as the control group. Body weights, fasting blood glucose (FBG), serum insulin and blood lipid levels of mice were measured. After 28 days of treatment with Gl-PS, body weights and serum insulin levels of the Gl-PS treated groups was significantly higher than that of the diabetic control group , whereas FBG levels was significantly lower. Moreover, total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels of the Gl-PS treated groups had dropped, whereas the high density lipoprotein cholesterol (HDL-C) levels had increased. In addition, according to acute toxicity studies, Gl-PS did not cause behavioral changes and any death of mice. These data suggest that Gl-PS has an antihyperglycemic effect. Furthermore, considering the Gl-PS effects on lipid proﬁle, it may be a potential hypolipidaemic agent, which will be a great advantage in treating diabetic conditions associated with atherosclerosis or hyperlipidemia.
Keywords: antihyperglycemic; ganoderma lucidum polysaccharides; streptozotocin; diabetic mice
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Li, F.; Zhang, Y.; Zhong, Z. Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice. Int. J. Mol. Sci. 2011, 12, 6135-6145.
Li F, Zhang Y, Zhong Z. Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice. International Journal of Molecular Sciences. 2011; 12(9):6135-6145.
Li, Fenglin; Zhang, Yiming; Zhong, Zhijian. 2011. "Antihyperglycemic Effect of Ganoderma Lucidum Polysaccharides on Streptozotocin-Induced Diabetic Mice." Int. J. Mol. Sci. 12, no. 9: 6135-6145.