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Int. J. Mol. Sci. 2011, 12(9), 5844-5852; doi:10.3390/ijms12095844
Article

Nucleated Polymerisation in the Presence of Pre-Formed Seed Filaments

, ,  and *
Received: 2 August 2011 / Revised: 30 August 2011 / Accepted: 30 August 2011 / Published: 9 September 2011
(This article belongs to the Special Issue Protein Aggregation)
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Abstract

We revisit the classical problem of nucleated polymerisation and derive a range of exact results describing polymerisation in systems intermediate between the well-known limiting cases of a reaction starting from purely soluble material and for a reaction where no new growth nuclei are formed.
Keywords: protein; aggregation; amyloid protein; aggregation; amyloid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cohen, S.I.A.; Vendruscolo, M.; Dobson, C.M.; Knowles, T.P.J. Nucleated Polymerisation in the Presence of Pre-Formed Seed Filaments. Int. J. Mol. Sci. 2011, 12, 5844-5852.

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