Next Article in Journal
Anti-Fatigue Properties of Tartary Buckwheat Extracts in Mice
Next Article in Special Issue
ATP-Dependent Chromatin Remodeling Factors and Their Roles in Affecting Nucleosome Fiber Composition
Previous Article in Journal
Molecular Basis for Chiral Selection in RNA Aminoacylation
Previous Article in Special Issue
Epigenetics: New Questions on the Response to Hypoxia
Int. J. Mol. Sci. 2011, 12(8), 4758-4769; doi:10.3390/ijms12084758
Review

Interplay of Dynamic Transcription and Chromatin Remodeling: Lessons from Yeast

1,2
,
1,2
 and
1,2,*
Received: 1 June 2011 / Revised: 15 July 2011 / Accepted: 20 July 2011 / Published: 25 July 2011
(This article belongs to the Special Issue Chromatin Assembly)
View Full-Text   |   Download PDF [233 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

Regulation of transcription involves dynamic rearrangements of chromatin structure. The budding yeast Saccharomyces cerevisiae has a variety of highly conserved factors necessary for these reconstructions. Chromatin remodelers, histone modifiers and histone chaperones directly associate to promoters and open reading frames of exposed genes and facilitate activation and repression of transcription. We compare two distinct patterns of induced transcription: Sustained transcribed genes switch to an activated state where they remain as long as the induction signal is present. In contrast, single pulsed transcribed genes show a quick and strong induction pulse resulting in high transcript levels followed by adaptation and repression to basal levels. We discuss intensively studied promoters and coding regions from both groups for their co-factor requirements during transcription. Interplay between chromatin restructuring factors and dynamic transcription is highly variable and locus dependent.
Keywords: chromatin; S. cerevisiae; stress; transcription chromatin; S. cerevisiae; stress; transcription
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Niederacher, G.; Klopf, E.; Schüller, C. Interplay of Dynamic Transcription and Chromatin Remodeling: Lessons from Yeast. Int. J. Mol. Sci. 2011, 12, 4758-4769.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert