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Interplay of Dynamic Transcription and Chromatin Remodeling: Lessons from Yeast
Max F. Perutz Laboratories, Department of Biochemistry and Cell Biology, University of Vienna, 1030 Vienna, Austria
Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, UFT Campus Tulln, 3430 Tulln, Austria
* Author to whom correspondence should be addressed.
Received: 1 June 2011; in revised form: 15 July 2011 / Accepted: 20 July 2011 / Published: 25 July 2011
Abstract: Regulation of transcription involves dynamic rearrangements of chromatin structure. The budding yeast Saccharomyces cerevisiae has a variety of highly conserved factors necessary for these reconstructions. Chromatin remodelers, histone modifiers and histone chaperones directly associate to promoters and open reading frames of exposed genes and facilitate activation and repression of transcription. We compare two distinct patterns of induced transcription: Sustained transcribed genes switch to an activated state where they remain as long as the induction signal is present. In contrast, single pulsed transcribed genes show a quick and strong induction pulse resulting in high transcript levels followed by adaptation and repression to basal levels. We discuss intensively studied promoters and coding regions from both groups for their co-factor requirements during transcription. Interplay between chromatin restructuring factors and dynamic transcription is highly variable and locus dependent.
Keywords: chromatin; S. cerevisiae; stress; transcription
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Niederacher, G.; Klopf, E.; Schüller, C. Interplay of Dynamic Transcription and Chromatin Remodeling: Lessons from Yeast. Int. J. Mol. Sci. 2011, 12, 4758-4769.
Niederacher G, Klopf E, Schüller C. Interplay of Dynamic Transcription and Chromatin Remodeling: Lessons from Yeast. International Journal of Molecular Sciences. 2011; 12(8):4758-4769.
Niederacher, Gerhard; Klopf, Eva; Schüller, Christoph. 2011. "Interplay of Dynamic Transcription and Chromatin Remodeling: Lessons from Yeast." Int. J. Mol. Sci. 12, no. 8: 4758-4769.