Abstract: Both genetic and epigenetic alterations can control the progression of cancer. Genetic alterations are impossible to reverse, while epigenetic alterations are reversible. This advantage suggests that epigenetic modifications should be preferred in therapy applications. DNA methyltransferases and histone deacetylases have become the primary targets for studies in epigenetic therapy. Some DNA methylation inhibitors and histone deacetylation inhibitors are approved by the US Food and Drug Administration as anti-cancer drugs. Therefore, the uses of epigenetic targets are believed to have great potential as a lasting favorable approach in treating breast cancer.
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Cai, F.-F.; Kohler, C.; Zhang, B.; Wang, M.-H.; Chen, W.-J.; Zhong, X.-Y. Epigenetic Therapy for Breast Cancer. Int. J. Mol. Sci. 2011, 12, 4465-4476.
Cai F-F, Kohler C, Zhang B, Wang M-H, Chen W-J, Zhong X-Y. Epigenetic Therapy for Breast Cancer. International Journal of Molecular Sciences. 2011; 12(7):4465-4476.
Cai, Feng-Feng; Kohler, Corina; Zhang, Bei; Wang, Ming-Hong; Chen, Wei-Jie; Zhong, Xiao-Yan. 2011. "Epigenetic Therapy for Breast Cancer." Int. J. Mol. Sci. 12, no. 7: 4465-4476.