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Int. J. Mol. Sci. 2011, 12(7), 4465-4476; doi:10.3390/ijms12074465
Review

Epigenetic Therapy for Breast Cancer

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Received: 20 May 2011 / Revised: 30 June 2011 / Accepted: 1 July 2011 / Published: 11 July 2011
(This article belongs to the Section Molecular Pathology)
View Full-Text   |   Download PDF [168 KB, 19 June 2014; original version 19 June 2014]

Abstract

Both genetic and epigenetic alterations can control the progression of cancer. Genetic alterations are impossible to reverse, while epigenetic alterations are reversible. This advantage suggests that epigenetic modifications should be preferred in therapy applications. DNA methyltransferases and histone deacetylases have become the primary targets for studies in epigenetic therapy. Some DNA methylation inhibitors and histone deacetylation inhibitors are approved by the US Food and Drug Administration as anti-cancer drugs. Therefore, the uses of epigenetic targets are believed to have great potential as a lasting favorable approach in treating breast cancer.
Keywords: breast cancer; epigenetic therapy; DNA methylation inhibitors; Histone deacetylation inhibitors breast cancer; epigenetic therapy; DNA methylation inhibitors; Histone deacetylation inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cai, F.-F.; Kohler, C.; Zhang, B.; Wang, M.-H.; Chen, W.-J.; Zhong, X.-Y. Epigenetic Therapy for Breast Cancer. Int. J. Mol. Sci. 2011, 12, 4465-4476.

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