Int. J. Mol. Sci. 2011, 12(6), 4027-4052; doi:10.3390/ijms12064027

Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics

1,2email, 1,2,* email, 1,2email and 3,4,* email
Received: 27 February 2011; in revised form: 3 June 2011 / Accepted: 3 June 2011 / Published: 15 June 2011
(This article belongs to the Special Issue A Systematic Development Method for Rational Drug Design)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Since the onset of antiviral therapy, viral resistance has compromised the clinical value of small-molecule drugs targeting pathogen components. As intracellular parasites, viruses complete their life cycle by hijacking a multitude of host-factors. Aiming at the latter rather than the pathogen directly, host-directed antiviral therapy has  emerged as a concept to counteract evolution of viral resistance and develop broad-spectrum drug classes. This approach is propelled by bioinformatics analysis of genome-wide screens that greatly enhance insights into the complex network of host-pathogen interactions and generate a shortlist of potential gene targets from a multitude of candidates, thus setting the stage for a new era of rational identification of drug targets for host-directed antiviral therapies. With particular emphasis on human immunodeficiency virus and influenza virus, two major human pathogens, we review screens employed to elucidate host-pathogen interactions and discuss the state of database ontology approaches applicable to defining a therapeutic endpoint. The value of this strategy for drug discovery is evaluated, and perspectives for bioinformatics-driven hit identification are outlined.
Keywords: genome-wide screening; pathway analysis; HIV; Influenza virus; bioinformatics; antiviral; target identification; RNAi; siRNA
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MDPI and ACS Style

Prussia, A.; Thepchatri, P.; Snyder, J.P.; Plemper, R.K. Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics. Int. J. Mol. Sci. 2011, 12, 4027-4052.

AMA Style

Prussia A, Thepchatri P, Snyder JP, Plemper RK. Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics. International Journal of Molecular Sciences. 2011; 12(6):4027-4052.

Chicago/Turabian Style

Prussia, Andrew; Thepchatri, Pahk; Snyder, James P.; Plemper, Richard K. 2011. "Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics." Int. J. Mol. Sci. 12, no. 6: 4027-4052.

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