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Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics
AbstractSince the onset of antiviral therapy, viral resistance has compromised the clinical value of small-molecule drugs targeting pathogen components. As intracellular parasites, viruses complete their life cycle by hijacking a multitude of host-factors. Aiming at the latter rather than the pathogen directly, host-directed antiviral therapy has emerged as a concept to counteract evolution of viral resistance and develop broad-spectrum drug classes. This approach is propelled by bioinformatics analysis of genome-wide screens that greatly enhance insights into the complex network of host-pathogen interactions and generate a shortlist of potential gene targets from a multitude of candidates, thus setting the stage for a new era of rational identification of drug targets for host-directed antiviral therapies. With particular emphasis on human immunodeficiency virus and influenza virus, two major human pathogens, we review screens employed to elucidate host-pathogen interactions and discuss the state of database ontology approaches applicable to defining a therapeutic endpoint. The value of this strategy for drug discovery is evaluated, and perspectives for bioinformatics-driven hit identification are outlined.
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Prussia, A.; Thepchatri, P.; Snyder, J.P.; Plemper, R.K. Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics. Int. J. Mol. Sci. 2011, 12, 4027-4052.View more citation formats
Prussia A, Thepchatri P, Snyder JP, Plemper RK. Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics. International Journal of Molecular Sciences. 2011; 12(6):4027-4052.Chicago/Turabian Style
Prussia, Andrew; Thepchatri, Pahk; Snyder, James P.; Plemper, Richard K. 2011. "Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics." Int. J. Mol. Sci. 12, no. 6: 4027-4052.