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Int. J. Mol. Sci. 2011, 12(6), 3846-3856; doi:10.3390/ijms12063846

Protective Role of α2HS-Glycoprotein in HBV-Associated Liver Failure

1
Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China
2
Department of Infectious Diseases, The Third Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, 410008, China
*
Author to whom correspondence should be addressed.
Received: 25 April 2011 / Revised: 25 May 2011 / Accepted: 3 June 2011 / Published: 10 June 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

n this study, levels of plasma α2-Heremans-Schmid glycoprotein, serum tumor necrosis factor-α, serum liver function parameters and short-term mortality were measured in 100 hepatitis B patients. Release of interleukin-6 and tumor necrosis factor-α from the lipopolysaccharide-stimulated peripheral blood mononuclear cells in the presence/absence of spermine and α2-Heremans-Schmid glycoprotein were analyzed by enzyme-linked immunosorbent assay to determine the significance and potential mechanism of α2-Heremans-Schmid glycoprotein in hepatitis B virus-associated liver damage. Results showed that serum α2-Heremans-Schmid glycoprotein levels in acute-on-chronic liver failure patients were significantly lower than that in chronic hepatitis B patients or healthy controls (p < 0.05). A negative dependence between serum human α2-Heremans-Schmid glycoprotein and tumor necrosis factor-α levels was observed. Interleukin-6 and tumor necrosis factor-α levels in the lipopolysaccharide-induced peripheral blood mononuclear cell supernates were significantly reduced by spermine and/or α2-Heremans-Schmid glycoprotein. The latter two proteins jointly inhibited cytokine release. These observations suggest that plasma α2-Heremans-Schmid glycoprotein is an independent marker of liver damage and a prognostic indicator of hepatitis B virus chronicity. It may reduce liver inflammation by partially inhibiting release of inflammatory factors from activated peripheral blood mononuclear cells.
Keywords: human fetuin-a; α2-Heremans-Schmid glycoprotein; spermine; acute-on-chronic liver failure human fetuin-a; α2-Heremans-Schmid glycoprotein; spermine; acute-on-chronic liver failure
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dai, X.-H.; Zhang, P.; Xiao, M.-F.; Zhou, R.-R.; Zhang, B.-X.; Hu, G.-S.; Huang, Z.-B.; Fan, X.-G. Protective Role of α2HS-Glycoprotein in HBV-Associated Liver Failure. Int. J. Mol. Sci. 2011, 12, 3846-3856.

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