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Int. J. Mol. Sci. 2011, 12(6), 3846-3856; doi:10.3390/ijms12063846
Article

Protective Role of α2HS-Glycoprotein in HBV-Associated Liver Failure

1
, 2
, 1
, 1
, 1
, 1
, 1
 and 1,*
1 Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China 2 Department of Infectious Diseases, The Third Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, 410008, China
* Author to whom correspondence should be addressed.
Received: 25 April 2011 / Revised: 25 May 2011 / Accepted: 3 June 2011 / Published: 10 June 2011
(This article belongs to the Section Bioinorganic Chemistry)
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Abstract

n this study, levels of plasma α2-Heremans-Schmid glycoprotein, serum tumor necrosis factor-α, serum liver function parameters and short-term mortality were measured in 100 hepatitis B patients. Release of interleukin-6 and tumor necrosis factor-α from the lipopolysaccharide-stimulated peripheral blood mononuclear cells in the presence/absence of spermine and α2-Heremans-Schmid glycoprotein were analyzed by enzyme-linked immunosorbent assay to determine the significance and potential mechanism of α2-Heremans-Schmid glycoprotein in hepatitis B virus-associated liver damage. Results showed that serum α2-Heremans-Schmid glycoprotein levels in acute-on-chronic liver failure patients were significantly lower than that in chronic hepatitis B patients or healthy controls (p < 0.05). A negative dependence between serum human α2-Heremans-Schmid glycoprotein and tumor necrosis factor-α levels was observed. Interleukin-6 and tumor necrosis factor-α levels in the lipopolysaccharide-induced peripheral blood mononuclear cell supernates were significantly reduced by spermine and/or α2-Heremans-Schmid glycoprotein. The latter two proteins jointly inhibited cytokine release. These observations suggest that plasma α2-Heremans-Schmid glycoprotein is an independent marker of liver damage and a prognostic indicator of hepatitis B virus chronicity. It may reduce liver inflammation by partially inhibiting release of inflammatory factors from activated peripheral blood mononuclear cells.
Keywords: human fetuin-a; α2-Heremans-Schmid glycoprotein; spermine; acute-on-chronic liver failure human fetuin-a; α2-Heremans-Schmid glycoprotein; spermine; acute-on-chronic liver failure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dai, X.-H.; Zhang, P.; Xiao, M.-F.; Zhou, R.-R.; Zhang, B.-X.; Hu, G.-S.; Huang, Z.-B.; Fan, X.-G. Protective Role of α2HS-Glycoprotein in HBV-Associated Liver Failure. Int. J. Mol. Sci. 2011, 12, 3846-3856.

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