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Int. J. Mol. Sci. 2011, 12(5), 2946-2957; doi:10.3390/ijms12052946
Communication

d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3

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Received: 6 April 2011 / Revised: 22 April 2011 / Accepted: 29 April 2011 / Published: 5 May 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

d-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding affinities of the conjugated SWCNTs to galectin-3 were quantified using electrochemical sensitivity measurements based on the differences in resistance together with typical I-V characterization. The electrochemical sensitivity measurements of the d-(+)-galactose-conjugated SWCNTs differed significantly between the samples with and without galectin-3. This indicates that d-(+)-galactose-conjugated SWCNTs are potentially useful electrochemical biosensors for the detection of cancer marker galectin-3.
Keywords: biosensor; cancer marker; galectin-3; galactose; single-walled carbon nanotubes biosensor; cancer marker; galectin-3; galactose; single-walled carbon nanotubes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Park, Y.K.; Bold, B.; Lee, W.K.; Jeon, M.H.; An, K.H.; Jeong, S.Y.; Shim, Y.K. d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3. Int. J. Mol. Sci. 2011, 12, 2946-2957.

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