Int. J. Mol. Sci. 2011, 12(5), 2946-2957; doi:10.3390/ijms12052946
Communication

d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3

Young Kum Park 1 email, Bayarmaa Bold 1 email, Woo Kyung Lee 1 email, Min Hyon Jeon 1 email, Kay Hyeok An 2 email, Seung Yol Jeong 3 email and Young Key Shim 1,* email
1 Department of Nano System Engineering, Inje University, Gimhae, 612-749, Korea 2 Carbon Valley R & D Division, Jeonju Institute of Machinery and Carbon Composites, Jeonju, 561-844, Korea 3 Nano Carbon Materials Research Group, Korea Electrotechnology Research Institute, Changwon, 641-120, Korea
* Author to whom correspondence should be addressed.
Received: 6 April 2011; in revised form: 22 April 2011 / Accepted: 29 April 2011 / Published: 5 May 2011
(This article belongs to the Section Material Sciences and Nanotechnology)
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Abstract: d-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding affinities of the conjugated SWCNTs to galectin-3 were quantified using electrochemical sensitivity measurements based on the differences in resistance together with typical I-V characterization. The electrochemical sensitivity measurements of the d-(+)-galactose-conjugated SWCNTs differed significantly between the samples with and without galectin-3. This indicates that d-(+)-galactose-conjugated SWCNTs are potentially useful electrochemical biosensors for the detection of cancer marker galectin-3.
Keywords: biosensor; cancer marker; galectin-3; galactose; single-walled carbon nanotubes

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Cite This Article

MDPI and ACS Style

Park, Y.K.; Bold, B.; Lee, W.K.; Jeon, M.H.; An, K.H.; Jeong, S.Y.; Shim, Y.K. d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3. Int. J. Mol. Sci. 2011, 12, 2946-2957.

AMA Style

Park YK, Bold B, Lee WK, Jeon MH, An KH, Jeong SY, Shim YK. d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3. International Journal of Molecular Sciences. 2011; 12(5):2946-2957.

Chicago/Turabian Style

Park, Young Kum; Bold, Bayarmaa; Lee, Woo Kyung; Jeon, Min Hyon; An, Kay Hyeok; Jeong, Seung Yol; Shim, Young Key. 2011. "d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3." Int. J. Mol. Sci. 12, no. 5: 2946-2957.

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