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Int. J. Mol. Sci. 2011, 12(4), 2678-2691; doi:10.3390/ijms12042678

Article

Preparation and Physicochemical Properties of 10-Hydroxycamptothecin (HCPT) Nanoparticles by Supercritical Antisolvent (SAS) Process

Xiuhua Zhao, Yuangang Zu* , Ru Jiang, Ying Wang, Yong Li, Qingyong Li, Dongmei Zhao, Baishi Zu, Baoyou Zhang, Zhiqiang Sun and Xiaonan Zhang

Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, China

* Author to whom correspondence should be addressed.

Received: 14 March 2011; in revised form: 13 April 2011 / Accepted: 18 April 2011 / Published: 20 April 2011

(This article belongs to the Section Material Sciences and Nanotechnology)

Download PDF Full-Text [759 KB, uploaded 20 April 2011 16:31 CEST]

Abstract: The goal of the present work was to study the feasibility of 10-hydroxycamptothecin (HCPT) nanoparticle preparation using supercritical antisolvent (SAS) precipitation. The influences of various experimental factors on the mean particle size (MPS) of HCPT nanoparticles were investigated. The optimum micronization conditions are determined as follows: HCPT solution concentration 0.5 mg/mL, the flow rate ratio of CO₂ and HCPT solution 19.55, precipitation temperature 35 °C and precipitation pressure 20 MPa. Under the optimum conditions, HCPT nanoparticles with a MPS of 180 ± 20.3 nm were obtained. Moreover, the HCPT nanoparticles obtained were characterized by Scanning electron microscopy, Dynamic light scattering, Fourier-transform infrared spectroscopy, High performance liquid chromatography-mass spectrometry, X-ray diffraction and Differential scanning calorimetry analyses. The physicochemical characterization results showed that the SAS process had not induced degradation of HCPT. Finally, the dissolution rates of HCPT nanoparticles were investigated and the results proved that there is a significant increase in dissolution rate compared to unprocessed HCPT.

Keywords: 10-hydroxycamptothecin; supercritical antisolvent; nanoparticles; preparation; physicochemical properties

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