Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions
AbstractA green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed.
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Noguez, M.O.; Marcelino, V.; Rodríguez, H.; Martín, O.; Martínez, J.O.; Arroyo, G.A.; Pérez, F.J.; Suárez, M.; Miranda, R. Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions. Int. J. Mol. Sci. 2011, 12, 2641-2649.
Noguez MO, Marcelino V, Rodríguez H, Martín O, Martínez JO, Arroyo GA, Pérez FJ, Suárez M, Miranda R. Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions. International Journal of Molecular Sciences. 2011; 12(4):2641-2649.Chicago/Turabian Style
Noguez, M. Olivia; Marcelino, Vanessa; Rodríguez, Hortensia; Martín, Osnieski; Martínez, Joel O.; Arroyo, Gabriel A.; Pérez, Francisco J.; Suárez, Margarita; Miranda, René. 2011. "Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions." Int. J. Mol. Sci. 12, no. 4: 2641-2649.