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Int. J. Mol. Sci. 2011, 12(4), 2641-2649; doi:10.3390/ijms12042641

Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions

Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán-UNAM, Estado de México, 54754, Mexico
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, 10400 Ciudad Habana, Cuba
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, D.F., 04510, Mexico
Author to whom correspondence should be addressed.
Received: 10 February 2011 / Revised: 14 March 2011 / Accepted: 30 March 2011 / Published: 18 April 2011
(This article belongs to the Section Green Chemistry)
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A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed. View Full-Text
Keywords: green approach; infrared irradiation; dihydropyridones; multicomponent reaction; Meldrum’s acid green approach; infrared irradiation; dihydropyridones; multicomponent reaction; Meldrum’s acid

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Noguez, M.O.; Marcelino, V.; Rodríguez, H.; Martín, O.; Martínez, J.O.; Arroyo, G.A.; Pérez, F.J.; Suárez, M.; Miranda, R. Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions. Int. J. Mol. Sci. 2011, 12, 2641-2649.

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