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Int. J. Mol. Sci. 2011, 12(4), 2641-2649; doi:10.3390/ijms12042641
Article

Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions

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 and
1,*
1 Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán-UNAM, Estado de México, 54754, Mexico 2 Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, 10400 Ciudad Habana, Cuba 3 Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, D.F., 04510, Mexico
* Author to whom correspondence should be addressed.
Received: 10 February 2011 / Revised: 14 March 2011 / Accepted: 30 March 2011 / Published: 18 April 2011
(This article belongs to the Section Green Chemistry)
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Abstract

A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed.
Keywords: green approach; infrared irradiation; dihydropyridones; multicomponent reaction; Meldrum’s acid green approach; infrared irradiation; dihydropyridones; multicomponent reaction; Meldrum’s acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Noguez, M.O.; Marcelino, V.; Rodríguez, H.; Martín, O.; Martínez, J.O.; Arroyo, G.A.; Pérez, F.J.; Suárez, M.; Miranda, R. Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions. Int. J. Mol. Sci. 2011, 12, 2641-2649.

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