This article is
- freely available
Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions
Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán-UNAM, Estado de México, 54754, Mexico
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, 10400 Ciudad Habana, Cuba
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, D.F., 04510, Mexico
* Author to whom correspondence should be addressed.
Received: 10 February 2011; in revised form: 14 March 2011 / Accepted: 30 March 2011 / Published: 18 April 2011
Abstract: A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed.
Keywords: green approach; infrared irradiation; dihydropyridones; multicomponent reaction; Meldrum’s acid
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Noguez, M.O.; Marcelino, V.; Rodríguez, H.; Martín, O.; Martínez, J.O.; Arroyo, G.A.; Pérez, F.J.; Suárez, M.; Miranda, R. Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions. Int. J. Mol. Sci. 2011, 12, 2641-2649.
Noguez MO, Marcelino V, Rodríguez H, Martín O, Martínez JO, Arroyo GA, Pérez FJ, Suárez M, Miranda R. Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions. International Journal of Molecular Sciences. 2011; 12(4):2641-2649.
Noguez, M. Olivia; Marcelino, Vanessa; Rodríguez, Hortensia; Martín, Osnieski; Martínez, Joel O.; Arroyo, Gabriel A.; Pérez, Francisco J.; Suárez, Margarita; Miranda, René. 2011. "Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions." Int. J. Mol. Sci. 12, no. 4: 2641-2649.