Next Article in Journal
In Vivo Anti-Tumor Activity of Polypeptide HM-3 Modified by Different Polyethylene Glycols (PEG)
Previous Article in Journal
Assessment of Acetylcholinesterase Activity Using Indoxylacetate and Comparison with the Standard Ellman’s Method
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2011, 12(4), 2641-2649; doi:10.3390/ijms12042641

Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions

1
Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán-UNAM, Estado de México, 54754, Mexico
2
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, 10400 Ciudad Habana, Cuba
3
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, D.F., 04510, Mexico
*
Author to whom correspondence should be addressed.
Received: 10 February 2011 / Revised: 14 March 2011 / Accepted: 30 March 2011 / Published: 18 April 2011
(This article belongs to the Section Green Chemistry)
View Full-Text   |   Download PDF [170 KB, uploaded 19 June 2014]   |  

Abstract

A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed.
Keywords: green approach; infrared irradiation; dihydropyridones; multicomponent reaction; Meldrum’s acid green approach; infrared irradiation; dihydropyridones; multicomponent reaction; Meldrum’s acid
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Noguez, M.O.; Marcelino, V.; Rodríguez, H.; Martín, O.; Martínez, J.O.; Arroyo, G.A.; Pérez, F.J.; Suárez, M.; Miranda, R. Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions. Int. J. Mol. Sci. 2011, 12, 2641-2649.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top