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Int. J. Mol. Sci. 2011, 12(4), 2158-2173; doi:10.3390/ijms12042158

Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO)

1
Department of Microbiology, University of Stellenbosch, 7602 Matieland (Stellenbosch), South Africa
2
Department of Chemistry and Polymer Science, University of Stellenbosch, 7602 Matieland (Stellenbosch), South Africa
*
Author to whom correspondence should be addressed.
Received: 27 January 2011 / Revised: 24 February 2011 / Accepted: 16 March 2011 / Published: 29 March 2011
(This article belongs to the Special Issue Bioactive Nanoparticles (special issue))
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Abstract

Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(D,L-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 °C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for various applications. View Full-Text
Keywords: bacteriocins; electrospinning; nanofiber; antimicrobial activity bacteriocins; electrospinning; nanofiber; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Heunis, T.; Bshena, O.; Klumperman, B.; Dicks, L. Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO). Int. J. Mol. Sci. 2011, 12, 2158-2173.

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