Int. J. Mol. Sci. 2011, 12(4), 2158-2173; doi:10.3390/ijms12042158
Article

Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO)

1 Department of Microbiology, University of Stellenbosch, 7602 Matieland (Stellenbosch), South Africa 2 Department of Chemistry and Polymer Science, University of Stellenbosch, 7602 Matieland (Stellenbosch), South Africa
* Author to whom correspondence should be addressed.
Received: 27 January 2011; in revised form: 24 February 2011 / Accepted: 16 March 2011 / Published: 29 March 2011
(This article belongs to the Special Issue Bioactive Nanoparticles)
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Abstract: Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(D,L-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 °C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for various applications.
Keywords: bacteriocins; electrospinning; nanofiber; antimicrobial activity

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MDPI and ACS Style

Heunis, T.; Bshena, O.; Klumperman, B.; Dicks, L. Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO). Int. J. Mol. Sci. 2011, 12, 2158-2173.

AMA Style

Heunis T, Bshena O, Klumperman B, Dicks L. Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO). International Journal of Molecular Sciences. 2011; 12(4):2158-2173.

Chicago/Turabian Style

Heunis, Tiaan; Bshena, Osama; Klumperman, Bert; Dicks, Leon. 2011. "Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO)." Int. J. Mol. Sci. 12, no. 4: 2158-2173.

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