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Int. J. Mol. Sci. 2011, 12(4), 2158-2173; doi:10.3390/ijms12042158
Article

Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO)

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Received: 27 January 2011 / Revised: 24 February 2011 / Accepted: 16 March 2011 / Published: 29 March 2011
(This article belongs to the Special Issue Bioactive Nanoparticles (special issue))
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Abstract

Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(D,L-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 °C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for various applications.
Keywords: bacteriocins; electrospinning; nanofiber; antimicrobial activity bacteriocins; electrospinning; nanofiber; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Heunis, T.; Bshena, O.; Klumperman, B.; Dicks, L. Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO). Int. J. Mol. Sci. 2011, 12, 2158-2173.

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