Next Article in Journal
Use of a Reflectance Spectroscopy Accessory for Optical Characterization of ZnO-Bi2O3-TiO2 Ceramics
Next Article in Special Issue
Nutritional Deficiencies and Phospholipid Metabolism
Previous Article in Journal
pH Dependent Molecular Self-Assembly of Octaphosphonate Porphyrin of Nanoscale Dimensions: Nanosphere and Nanorod Aggregates
Previous Article in Special Issue
Phospholipases A1
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2011, 12(3), 1474-1495; doi:10.3390/ijms12031474

Integrated Lipidomics in the Secreted Phospholipase A2 Biology

Lipid Metabolism Project, The Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
*
Author to whom correspondence should be addressed.
Received: 30 January 2011 / Revised: 18 February 2011 / Accepted: 24 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Phospholipids: Molecular Sciences)
View Full-Text   |   Download PDF [764 KB, uploaded 19 June 2014]   |  

Abstract

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or related enzymes, which are subdivided into several subgroups based on their structures, catalytic mechanisms, localizations and evolutionary relationships. More than one third of the PLA2 enzymes belong to the secreted PLA2 (sPLA2) family, which consists of low-molecular-weight, Ca2+-requiring extracellular enzymes, with a His-Asp catalytic dyad. Individual sPLA2 isoforms exhibit unique tissue and cellular localizations and enzymatic properties, suggesting their distinct pathophysiological roles. Recent studies using transgenic and knockout mice for several sPLA2 isoforms, in combination with lipidomics approaches, have revealed their distinct contributions to various biological events. Herein, we will describe several examples of sPLA2-mediated phospholipid metabolism in vivo, as revealed by integrated analysis of sPLA2 transgenic/knockout mice and lipid mass spectrometry. Knowledge obtained from this approach greatly contributes to expanding our understanding of the sPLA2 biology and pathophysiology. View Full-Text
Keywords: phospholipase A2; phospholipid; lipidomics; transgenic mouse; knockout mouse phospholipase A2; phospholipid; lipidomics; transgenic mouse; knockout mouse
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Murakami, M.; Sato, H.; Taketomi, Y.; Yamamoto, K. Integrated Lipidomics in the Secreted Phospholipase A2 Biology. Int. J. Mol. Sci. 2011, 12, 1474-1495.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top