Next Article in Journal
Structural Requirements of N-Substituted Spiropiperidine Analogues as Agonists of Nociceptin/Orphanin FQ Receptor
Next Article in Special Issue
Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for Carcinogenesis
Previous Article in Journal
The Wnt and BMP Families of Signaling Morphogens at the Vertebrate Neuromuscular Junction
Previous Article in Special Issue
Caffeine Abolishes the Ultraviolet-Induced REV3 Translesion Replication Pathway in Mouse Cells
Int. J. Mol. Sci. 2011, 12(12), 8947-8960; doi:10.3390/ijms12128947
Review

The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis

1
,
1
,
1
 and
1,2,*
Received: 11 October 2011 / Revised: 15 November 2011 / Accepted: 30 November 2011 / Published: 6 December 2011
(This article belongs to the Special Issue UV-Induced Cell Death)
View Full-Text   |   Download PDF [327 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.
Keywords: UV; sunburn cells; E2F; apoptosis UV; sunburn cells; E2F; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Hazar-Rethinam, M.; Endo-Munoz, L.; Gannon, O.; Saunders, N. The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis. Int. J. Mol. Sci. 2011, 12, 8947-8960.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert