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Int. J. Mol. Sci. 2011, 12(12), 8947-8960; doi:10.3390/ijms12128947
Review

The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis

1
,
1
,
1
 and
1,2,*
1 Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia 2 School of Biomedical Sciences, University of Queensland, Queensland 4072, Australia
* Author to whom correspondence should be addressed.
Received: 11 October 2011 / Revised: 15 November 2011 / Accepted: 30 November 2011 / Published: 6 December 2011
(This article belongs to the Special Issue UV-Induced Cell Death)
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Abstract

The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.
Keywords: UV; sunburn cells; E2F; apoptosis UV; sunburn cells; E2F; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hazar-Rethinam, M.; Endo-Munoz, L.; Gannon, O.; Saunders, N. The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis. Int. J. Mol. Sci. 2011, 12, 8947-8960.

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