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Int. J. Mol. Sci. 2011, 12(12), 8947-8960; doi:10.3390/ijms12128947

The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis

1 Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia 2 School of Biomedical Sciences, University of Queensland, Queensland 4072, Australia
* Author to whom correspondence should be addressed.
Received: 11 October 2011 / Revised: 15 November 2011 / Accepted: 30 November 2011 / Published: 6 December 2011
(This article belongs to the Special Issue UV-Induced Cell Death)
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The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.
Keywords: UV; sunburn cells; E2F; apoptosis UV; sunburn cells; E2F; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hazar-Rethinam, M.; Endo-Munoz, L.; Gannon, O.; Saunders, N. The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis. Int. J. Mol. Sci. 2011, 12, 8947-8960.

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