Int. J. Mol. Sci. 2011, 12(12), 8489-8501; doi:10.3390/ijms12128489
Article

Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397 Cytoplasmic Expression and the Prognostic Value in Advanced Epithelial Ovarian Carcinoma

Dong-Mei Fan 1,2 email and Hui-Rong Shi 1,* email
1 Department of Obstetrics and Gynecology, The First Affiliated Hospital, Zhengzhou University, NO.1 Jianshe Road, Zhengzhou 450052, China 2 Department of Gynecology, The First Affiliated Hospital of Henan University of Scientific and Technology, Luoyang 471003, China
* Author to whom correspondence should be addressed.
Received: 9 October 2011; in revised form: 3 November 2011 / Accepted: 7 November 2011 / Published: 29 November 2011
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Abstract: Background: Deletion in liver cancer gene (DLC1) and phosphorylated focal adhesion kinase (p-FAK) have recently been reported as metastasis-related genes. However, the roles and prognostic values of their expression in epithelial ovarian carcinomas (EOCs) remain unclear. Methods: The expression and prognostic value of DLC1 and p-FAK Y397 in EOC were evaluated by immunohistochemistry and multivariate analysis. Results: Low expression of DLC1 and high expression of p-FAK Y397 were found in the 76 cases of EOC. The expression of DLC1 and p-FAK Y397 were negatively correlated. Multivariate analysis showed that the combination of them was an independent prognostic marker of EOC (P = 0.0319). Conclusions: DLC1 and pFAK Y397 had an association with the clinicopathologic characteristics of EOC. Expression of neither of these genes was a prognostic factor alone, but the combination revealed a significant prognostic value in the 60 cases of advanced stage EOC.
Keywords: DLC1; gynecologic cancers; ovarian carcinoma; prognosis; p-FAK

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MDPI and ACS Style

Fan, D.-M.; Shi, H.-R. Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397 Cytoplasmic Expression and the Prognostic Value in Advanced Epithelial Ovarian Carcinoma. Int. J. Mol. Sci. 2011, 12, 8489-8501.

AMA Style

Fan D-M, Shi H-R. Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397 Cytoplasmic Expression and the Prognostic Value in Advanced Epithelial Ovarian Carcinoma. International Journal of Molecular Sciences. 2011; 12(12):8489-8501.

Chicago/Turabian Style

Fan, Dong-Mei; Shi, Hui-Rong. 2011. "Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397 Cytoplasmic Expression and the Prognostic Value in Advanced Epithelial Ovarian Carcinoma." Int. J. Mol. Sci. 12, no. 12: 8489-8501.

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