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Int. J. Mol. Sci. 2011, 12(12), 8476-8488; doi:10.3390/ijms12128476

Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Authors to whom correspondence should be addressed.
Received: 6 September 2011 / Revised: 5 November 2011 / Accepted: 14 November 2011 / Published: 29 November 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers.
Keywords: lipoic acid; broiler; antioxidant capability lipoic acid; broiler; antioxidant capability
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, P.; Ma, Q.-G.; Ji, C.; Zhang, J.-Y.; Zhao, L.-H.; Zhang, Y.; Jie, Y.-Z. Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers. Int. J. Mol. Sci. 2011, 12, 8476-8488.

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