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Int. J. Mol. Sci. 2011, 12(12), 8466-8475; doi:10.3390/ijms12128466

Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers

1
Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
2
Dermatology Service, Ramon y Cajal Hospital, Madrid 28034, Spain
3
Dermatology Service, Hospital San Jorge, Huesca 22004, Spain
4
School of Natural Sciences, University College, Fairleigh Dickinson University, Teaneck, NJ 07666, USA
5
Biology Department, Sciences School, Universidad Autónoma de Madrid, Madrid 28049, Spain
*
Author to whom correspondence should be addressed.
Received: 27 September 2011 / Revised: 31 October 2011 / Accepted: 21 November 2011 / Published: 29 November 2011
(This article belongs to the Special Issue Advances in Nutraceutical Research)
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Abstract

Many phytochemicals are endowed with photoprotective properties, i.e., the capability to prevent the harmful effects of excessive exposure to ultraviolet (UV) light. These effects include photoaging and skin cancer, and immunosuppression. Photoprotection is endowed through two major modes of action: UV absorption or reflection/scattering; and tissue repair post-exposure. We and others have uncovered the photoprotective properties of an extract of the fern Polypodium leucotomos (commercial name Fernblock). Fernblock is an all-natural antioxidant extract, administered both topically (on the skin) or orally. It inhibits generation of reactive oxygen species (ROS) production induced by UV including superoxide anion. It also prevents damage to the DNA, inhibits UV-induced AP1 and NF-κB, and protects endogenous skin natural antioxidant systems, i.e., CAT, GSH, and GSSR. Its photoprotective effects at a cellular level include a marked decrease of UV-mediated cellular apoptosis and necrosis and a profound inhibition of extracellular matrix remodeling. These molecular and cellular effects translate into long-term inhibition of photoaging and carcinogenesis that, together with its lack of toxicity, postulate its use as a novel-generation photoprotective nutriceutical of phytochemical origin. View Full-Text
Keywords: Polypodium leucotomos extract; photoprotection; oral sunscreen; antioxidant; photoaging; skin cancer Polypodium leucotomos extract; photoprotection; oral sunscreen; antioxidant; photoaging; skin cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gonzalez, S.; Gilaberte, Y.; Philips, N.; Juarranz, A. Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers. Int. J. Mol. Sci. 2011, 12, 8466-8475.

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