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Int. J. Mol. Sci. 2011, 12(11), 8052-8062; doi:10.3390/ijms12118052

3,3′-Diethylthiatricarbocyanine Iodide: A Highly Sensitive Chiroptical Reporter of DNA Helicity and Sequence

1
Department of Chemistry, University of Wyoming, Laramie, WY 82071, USA
2
Doane College, 1014 Boswell, Crete, NE 68333, USA
*
Author to whom correspondence should be addressed.
Received: 21 October 2011 / Revised: 2 November 2011 / Accepted: 7 November 2011 / Published: 16 November 2011
(This article belongs to the Special Issue Applications of Circular Dichroism)
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Abstract

Using UV-vis absorption and circular dichroism (CD) spectroscopies, we explored the binding interactions of 3,3′-diethylthiatricarbocyanine iodide (Cy7) with polynucleotides of different sequences and helicity. CD showed to be a very diagnostic tool giving different spectroscopic chiroptical signatures for all explored DNA sequences upon Cy7 binding. Cy7 was able to spectroscopically discriminate between the right handed B-DNA of poly(dG-dC)2 and its left handed Z-DNA counterpart induced by spermine or Co(III)hexamine via nearly opposite induced circular dichroic signal. View Full-Text
Keywords: Cy7 cyanine dye; left-handed Z-DNA; circular dichroism; DNA recognition; sensing Cy7 cyanine dye; left-handed Z-DNA; circular dichroism; DNA recognition; sensing
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MDPI and ACS Style

Choi, J.K.; D’Urso, A.; Trauernicht, M.; Shabbir-Hussain, M.; Holmes, A.E.; Balaz, M. 3,3′-Diethylthiatricarbocyanine Iodide: A Highly Sensitive Chiroptical Reporter of DNA Helicity and Sequence. Int. J. Mol. Sci. 2011, 12, 8052-8062.

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