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Int. J. Mol. Sci. 2011, 12(11), 7469-7480; doi:10.3390/ijms12117469
Review

Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants

1,* , 2
, 3
 and 1
Received: 20 September 2011; in revised form: 13 October 2011 / Accepted: 24 October 2011 / Published: 31 October 2011
(This article belongs to the Special Issue Advances in Computational Toxicology)
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Abstract: Physiologically Based Pharmacokinetic (PBPK) models can be used to determine the internal dose and strengthen exposure assessment. Many PBPK models are available, but they are not easily accessible for field use. The Agency for Toxic Substances and Disease Registry (ATSDR) has conducted translational research to develop a human PBPK model toolkit by recoding published PBPK models. This toolkit, when fully developed, will provide a platform that consists of a series of priority PBPK models of environmental pollutants. Presented here is work on recoded PBPK models for volatile organic compounds (VOCs) and metals. Good agreement was generally obtained between the original and the recoded models. This toolkit will be available for ATSDR scientists and public health assessors to perform simulations of exposures from contaminated environmental media at sites of concern and to help interpret biomonitoring data. It can be used as screening tools that can provide useful information for the protection of the public.
Keywords: volatile organic compounds; VOCs; metals; PBPK; toxicokinetic; National Health and Nutrition Examination Survey (NHANES) volatile organic compounds; VOCs; metals; PBPK; toxicokinetic; National Health and Nutrition Examination Survey (NHANES)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ruiz, P.; Ray, M.; Fisher, J.; Mumtaz, M. Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants. Int. J. Mol. Sci. 2011, 12, 7469-7480.

AMA Style

Ruiz P, Ray M, Fisher J, Mumtaz M. Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants. International Journal of Molecular Sciences. 2011; 12(11):7469-7480.

Chicago/Turabian Style

Ruiz, Patricia; Ray, Meredith; Fisher, Jeffrey; Mumtaz, Moiz. 2011. "Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants." Int. J. Mol. Sci. 12, no. 11: 7469-7480.


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