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• Ruiz, P
• Ray, M
• Fisher, J
• Mumtaz, M
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• Ruiz, P
• Ray, M
• Fisher, J
• Mumtaz, M
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• Ruiz, P
• Ray, M
• Fisher, J
• Mumtaz, M

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Int. J. Mol. Sci. 2011, 12(11), 7469-7480; doi:10.3390/ijms12117469

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Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants

Patricia Ruiz ^1,* , Meredith Ray ² , Jeffrey Fisher ³  and Moiz Mumtaz ¹

¹ Computational Toxicology and Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA ² Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA ³ USFDA, National Center for Toxicological Research, Jefferson, AR 72079, USA

* Author to whom correspondence should be addressed.

Received: 20 September 2011; in revised form: 13 October 2011 / Accepted: 24 October 2011 / Published: 31 October 2011

(This article belongs to the Special Issue Advances in Computational Toxicology)

Download PDF Full-Text [255 KB, uploaded 31 October 2011 11:09 CET]

Abstract: Physiologically Based Pharmacokinetic (PBPK) models can be used to determine the internal dose and strengthen exposure assessment. Many PBPK models are available, but they are not easily accessible for field use. The Agency for Toxic Substances and Disease Registry (ATSDR) has conducted translational research to develop a human PBPK model toolkit by recoding published PBPK models. This toolkit, when fully developed, will provide a platform that consists of a series of priority PBPK models of environmental pollutants. Presented here is work on recoded PBPK models for volatile organic compounds (VOCs) and metals. Good agreement was generally obtained between the original and the recoded models. This toolkit will be available for ATSDR scientists and public health assessors to perform simulations of exposures from contaminated environmental media at sites of concern and to help interpret biomonitoring data. It can be used as screening tools that can provide useful information for the protection of the public.

Keywords: volatile organic compounds; VOCs; metals; PBPK; toxicokinetic; National Health and Nutrition Examination Survey (NHANES)

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