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Int. J. Mol. Sci. 2011, 12(10), 7186-7198; doi:10.3390/ijms12107186
Article

Metal Complexes of Diisopropylthiourea: Synthesis, Characterization and Antibacterial Studies

*  and
Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa
* Author to whom correspondence should be addressed.
Received: 5 August 2011 / Revised: 30 September 2011 / Accepted: 11 October 2011 / Published: 21 October 2011
(This article belongs to the Section Bioinorganic Chemistry)
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Abstract

Co(II), Cu(II), Zn(II) and Fe(III) complexes of diisopropylthiourea have been synthesized and characterized by elemental analyses, molar conductivity, magnetic susceptibility, FTIR and electronic spectroscopy. The compounds are non-electrolytes in solution and spectroscopic data of the complexes are consistent with 4-coordinate geometry for the metal(II) complexes and six coordinate octahedral for Fe(III) complex. The complexes were screened for their antibacterial activities against six bacteria: Escherichia coli, Pseudomonas auriginosa, Klebsiella pneumoniae, Bacillus cereus, Staphylococcus aureus and Bacillus pumilus. The complexes showed varied antibacterial activities and their minimum inhibitory concentrations (MICs) were determined.
Keywords: metal complexes; diisopropylthiourea; antibacterial; drug resistance metal complexes; diisopropylthiourea; antibacterial; drug resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ajibade, P.A.; Zulu, N.H. Metal Complexes of Diisopropylthiourea: Synthesis, Characterization and Antibacterial Studies. Int. J. Mol. Sci. 2011, 12, 7186-7198.

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