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Int. J. Mol. Sci. 2011, 12(10), 6597-6618; doi:10.3390/ijms12106597
Article

Crystallization Study and Comparative in Vitroin Vivo Hydrolysis of PLA Reinforcement Ligament

1
, 1
, 1, 1
, 2
 and 2,*
Received: 27 June 2011; in revised form: 24 September 2011 / Accepted: 28 September 2011 / Published: 10 October 2011
(This article belongs to the Special Issue Biodegradability of Materials in Biomedical Applications 2011)
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Abstract: In the present work, the crystallization behavior and in vitroin vivo hydrolysis rates of PLA absorbable reinforcement ligaments used in orthopaedics for the repair and reinforcement of articulation instabilities were studied. Tensile strength tests showed that this reinforcement ligament has similar mechanical properties to Fascia Latta, which is an allograft sourced from the ilio-tibial band of the human body. The PLA reinforcement ligament is a semicrystalline material with a glass transition temperature around 61 °C and a melting point of ~178 °C. Dynamic crystallization revealed that, although the crystallization rates of the material are slow, they are faster than the often-reported PLA crystallization rates. Mass loss and molecular weight reduction measurements showed that in vitro hydrolysis at 50 °C initially takes place at a slow rate, which gets progressively higher after 30–40 days. As found from SEM micrographs, deterioration of the PLA fibers begins during this time. Furthermore, as found from in vivo hydrolysis in the human body, the PLA reinforcement ligament is fully biocompatible and after 6 months of implantation is completely covered with flesh. However, the observed hydrolysis rate from in vivo studies was slow due to high molecular weight and degree of crystallinity.
Keywords: PLA; reinforcement ligaments; orthopaedics; crystallization; in vitroin vivo hydrolysis PLA; reinforcement ligaments; orthopaedics; crystallization; in vitroin vivo hydrolysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Beslikas, T.; Gigis, I.; Goulios, V.; Christoforides, J.; Papageorgiou, G.Z.; Bikiaris, D.N. Crystallization Study and Comparative in Vitroin Vivo Hydrolysis of PLA Reinforcement Ligament. Int. J. Mol. Sci. 2011, 12, 6597-6618.

AMA Style

Beslikas T, Gigis I, Goulios V, Christoforides J, Papageorgiou GZ, Bikiaris DN. Crystallization Study and Comparative in Vitroin Vivo Hydrolysis of PLA Reinforcement Ligament. International Journal of Molecular Sciences. 2011; 12(10):6597-6618.

Chicago/Turabian Style

Beslikas, Theodore; Gigis, Ioannis; Goulios, Vasilios; Christoforides, John; Papageorgiou, George Z.; Bikiaris, Dimitrios N. 2011. "Crystallization Study and Comparative in Vitroin Vivo Hydrolysis of PLA Reinforcement Ligament." Int. J. Mol. Sci. 12, no. 10: 6597-6618.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert