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Int. J. Mol. Sci. 2011, 12(1), 588-612; doi:10.3390/ijms12010588
Review

Phospholipases A1

1
 and
2,*
Received: 15 December 2010 / Revised: 7 January 2011 / Accepted: 11 January 2011 / Published: 18 January 2011
(This article belongs to the Special Issue Phospholipids: Molecular Sciences)
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Abstract

Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA1 enzymes. Where their function is known, PLA1s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.
Keywords: phospholipase A1; phospholipid; lysophospholipid phospholipase A1; phospholipid; lysophospholipid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Richmond, G.S.; Smith, T.K. Phospholipases A1. Int. J. Mol. Sci. 2011, 12, 588-612.

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