Int. J. Mol. Sci. 2011, 12(1), 588-612; doi:10.3390/ijms12010588
Review

Phospholipases A1

Gregory S. Richmond 1 email and Terry K. Smith 2,* email
1 Agilent Technologies, Molecular Separations, Santa Clara, CA 95051, USA 2 Centre for Biomolecular Sciences, The North Haugh, The University, St. Andrews, KY16 9ST, Scotland, UK
* Author to whom correspondence should be addressed.
Received: 15 December 2010; in revised form: 7 January 2011 / Accepted: 11 January 2011 / Published: 18 January 2011
(This article belongs to the Special Issue Phospholipids: Molecular Sciences)
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Abstract: Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA1 enzymes. Where their function is known, PLA1s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.
Keywords: phospholipase A1; phospholipid; lysophospholipid

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MDPI and ACS Style

Richmond, G.S.; Smith, T.K. Phospholipases A1. Int. J. Mol. Sci. 2011, 12, 588-612.

AMA Style

Richmond GS, Smith TK. Phospholipases A1. International Journal of Molecular Sciences. 2011; 12(1):588-612.

Chicago/Turabian Style

Richmond, Gregory S.; Smith, Terry K. 2011. "Phospholipases A1." Int. J. Mol. Sci. 12, no. 1: 588-612.

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