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Agilent Technologies, Molecular Separations, Santa Clara, CA 95051, USA
Centre for Biomolecular Sciences, The North Haugh, The University, St. Andrews, KY16 9ST, Scotland, UK
* Author to whom correspondence should be addressed.
Received: 15 December 2010; in revised form: 7 January 2011 / Accepted: 11 January 2011 / Published: 18 January 2011
Abstract: Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA1 enzymes. Where their function is known, PLA1s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.
Keywords: phospholipase A1; phospholipid; lysophospholipid
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Cite This Article
MDPI and ACS Style
Richmond, G.S.; Smith, T.K. Phospholipases A1. Int. J. Mol. Sci. 2011, 12, 588-612.
Richmond GS, Smith TK. Phospholipases A1. International Journal of Molecular Sciences. 2011; 12(1):588-612.
Richmond, Gregory S.; Smith, Terry K. 2011. "Phospholipases A1." Int. J. Mol. Sci. 12, no. 1: 588-612.