Next Article in Journal
Insight into a Novel p53 Single Point Mutation (G389E) by Molecular Dynamics Simulations
Previous Article in Journal
Cell Surface Markers in Colorectal Cancer Prognosis
Int. J. Mol. Sci. 2011, 12(1), 114-127; doi:10.3390/ijms12010114
Article

Behavioral Impairment and Oxidative Damage Induced by Chronic Application of Nonylphenol

1,* , 2
 and 1
Received: 5 November 2010; in revised form: 20 December 2010 / Accepted: 28 December 2010 / Published: 30 December 2010
(This article belongs to the Section Molecular Toxicology)
View Full-Text   |   Download PDF [434 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, which are widely used in the production of industrial and consumer surfactants. The aim of the present study was to evaluate the effect of NP on the antioxidant capacity and cognitive ability of mice. NP was given orally by gavages at doses of 0, 50, 100, and 200 mg kg−1 d−1 for 90 days. The results showed that NP significantly decreased the activity of superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) and at the same time increased malondialdehyde (MDA) levels in mice brains. Exploration, memory function and ability to learn a novel task were significantly decreased in NP fed mice. These results indicate that chronic high dose of NP exposure has the potential to generate oxidative stress and induce the cognitive impairment in male mice.
Keywords: nonylphenol; brain; oxidative stress; behavior impairment nonylphenol; brain; oxidative stress; behavior impairment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Mao, Z.; Zheng, Y.-L.; Zhang, Y.-Q. Behavioral Impairment and Oxidative Damage Induced by Chronic Application of Nonylphenol. Int. J. Mol. Sci. 2011, 12, 114-127.

AMA Style

Mao Z, Zheng Y-L, Zhang Y-Q. Behavioral Impairment and Oxidative Damage Induced by Chronic Application of Nonylphenol. International Journal of Molecular Sciences. 2011; 12(1):114-127.

Chicago/Turabian Style

Mao, Zhen; Zheng, Yuan-Lin; Zhang, Yan-Qiu. 2011. "Behavioral Impairment and Oxidative Damage Induced by Chronic Application of Nonylphenol." Int. J. Mol. Sci. 12, no. 1: 114-127.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert